TSC22D1 and FBN3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TSC22D1	FBN3
Description		TSC22 domain family member 1	fibrillin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Microfibril Extracellular Region Extracellular Matrix
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation	Glucose Metabolic Process Signal Transduction Glucose Homeostasis Camera-type Eye Development Embryonic Eye Morphogenesis
Pathways			Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)	Attention deficit hyperactivity disorder ( 30563984) Macular telangiectasia type 2 ( 33654266) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1	13 interacting genes: ANXA7 BID C11orf58 CDKN1A DAZAP2 GADD45A GSK3B NUDT21 PIK3R3 RPN2 RPS6KA6 TK1 TSC22D1
Entrez ID		8848	84467
HPRD ID		07414	10538
Ensembl ID		ENSG00000102804	ENSG00000142449
Uniprot IDs		A8K3Y6 Q15714	A0A494C0D8 A8KAY2 Q75N90
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Signal Transduction In Response To DNA Damage Positive Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Nuclear Body Protein Serine/threonine Kinase Binding Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Catalytic Activity Regulation Of Programmed Cell Death Negative Regulation Of Developmental Process Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Regulation Of Membrane Permeability Negative Regulation Of Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process PCNA-p21 Complex Cell Cycle G1/S Phase Transition Negative Regulation Of Cardiac Muscle Tissue Regeneration G1/S Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein P53 Binding Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Stem Cell Differentiation Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Insulin Receptor Signaling Pathway Thymidine Kinase Activity Positive Regulation Of Pro-B Cell Differentiation Negative Regulation Of Embryonic Development DNA Damage Response Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction DNA Synthesis Involved In Mitotic DNA Replication Protein Tetramerization Positive Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Mesoderm Development Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Protein Phosphorylation Cellular Response To Cell-matrix Adhesion Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation
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