TSC22D1 and KMT2C

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TSC22D1	KMT2C
Description		TSC22 domain family member 1	lysine methyltransferase 2C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Acyltransferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1	14 interacting genes: APPL2 DPY30 H2AC4 H2BC3 H3-4 H3C1 H3C14 H4C1 JUN MAPK14 MTNR1B RNF10 SMARCB1 TSC22D1
Entrez ID		8848	58508
HPRD ID		07414	06016
Ensembl ID		ENSG00000102804	ENSG00000055609
Uniprot IDs		A8K3Y6 Q15714	Q8NEZ4
PDB IDs			2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC 7W6L
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Protein-DNA Complex Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization DNA Binding Chromosome Negative Regulation Of Cell Population Proliferation Nucleus Regulation Of Cell Development Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Host-mediated Activation Of Viral Transcription CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Cell Population Proliferation Response To Muscle Stretch Cellular Component Assembly Host-mediated Perturbation Of Viral Transcription Nuclear Chromosome Regulation Of Hemopoiesis Chromosome, Telomeric Region Host-mediated Activation Of Viral Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Localization To Chromosome, Centromeric Region Regulation Of Multicellular Organismal Development Positive Regulation Of Myoblast Differentiation Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Protein Localization To Chromatin Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Biosynthetic Process Regulation Of D-glucose Import Nucleoplasm Negative Regulation Of Cell Development Regulation Of Developmental Process Leading Edge Cell Differentiation Positive Regulation Of Macropinocytosis Regulation Of D-glucose Transmembrane Transport Regulation Of Myoblast Differentiation Host-mediated Perturbation Of Viral Process Negative Regulation Of Cell Differentiation
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