TSC22D1 and MAP3K12

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSC22D1	MAP3K12
Description		TSC22 domain family member 1	mitogen-activated protein kinase kinase kinase 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation	Protein Phosphorylation JNK Cascade Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Primary Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)	Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1	16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1
Entrez ID		8848	7786
HPRD ID		07414	02709
Ensembl ID		ENSG00000102804	ENSG00000139625
Uniprot IDs		A8K3Y6 Q15714	Q12852
PDB IDs			5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2 8DEG 8OUR 8OUS 8OUT 9CDX 9CDY
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	MAPK Cascade JNK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Programmed Cell Death MAP-kinase Scaffold Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling JUN Kinase Kinase Activity Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Mitogen-activated Protein Kinase Kinase Binding JUN Kinase Binding Cytosol Protein Kinase Activity Intracellular Signal Transduction Regulation Of Motor Neuron Apoptotic Process MAP Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding MAP Kinase Activity Regulation Of CD8-positive, Alpha-beta T Cell Activation Kinase Activity MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Serine Kinase Activity Signal Transduction Perinuclear Region Of Cytoplasm Protein Serine/threonine Kinase Activity Transferase Activity Protein Kinase Binding Kinesin Binding Protein Kinase Inhibitor Activity Multivesicular Body, Internal Vesicle Lumen Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?