TSC22D1 and ASAH1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSC22D1	ASAH1
Description		TSC22 domain family member 1	N-acylsphingosine amidohydrolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Early Endosome Endoplasmic Reticulum Membrane Lysosomal Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	Transcription Corepressor Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Nuclear Receptor Binding N-acylsphingosine Amidohydrolase Activity Fatty Acid Amide Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation	Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Ceramide Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor
Pathways			Neutrophil degranulation Glycosphingolipid catabolism Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs
Diseases			Farber lipogranulomatosis; Farber disease
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)	Atrial fibrillation ( 28416818 29892015 30061737) Night sleep phenotypes ( 27126917) Obesity ( 21552555) Type 2 diabetes ( 32499647)
Interacting Genes		51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1	6 interacting genes: CAMK1D HSPB2 SETDB1 SMPD1 SRPK1 TSC22D1
Entrez ID		8848	427
HPRD ID		07414	01969
Ensembl ID		ENSG00000102804	ENSG00000104763
Uniprot IDs		A8K3Y6 Q15714	A0A1B0GUE3 A8K0B6 Q13510 Q53H01
PDB IDs			5U7Z 6MHM
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phosphatidylcholine Phospholipase C Activity Regulation Of Viral Life Cycle Positive Regulation Of Apoptotic Process Acid Sphingomyelin Phosphodiesterase Activity Positive Regulation Of Viral Process Regulation Of Viral Process Termination Of Signal Transduction Somatic Muscle Development Positive Regulation Of Endocytosis Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Sphingomyelin Catabolic Process Lamellar Body Sphingomyelin Phosphodiesterase Activity Histone H3K9 Monomethyltransferase Activity Endolysosome Histone H3K9me2 Methyltransferase Activity Positive Regulation Of Respiratory Burst Positive Regulation Of CREB Transcription Factor Activity Histone H3K9 Methyltransferase Activity
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