TSC22D1 and RPL5

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TSC22D1	RPL5
Gene Name		TSC22 domain family, member 1	ribosomal protein L5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956)	Height ( 20881960) Multiple sclerosis ( 19525955 17660530)
Protein-Protein Interactions		49 interactors: A2M APLP1 ASAH1 C14orf1 C9orf9 CACNA1A CARHSP1 CCDC90B CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED FAF1 FAM20C FBN3 GNB2 GNB5 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 OTUB1 PDHB PRKCI PTN QARS RGS1 RPL5 SETDB1 SP110 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WDYHV1 WIZ WNK1 ZC3HC1	21 interactors: CSNK2A1 CSNK2B DCC EIF5A HARS IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL PDCD4 PPM1D SPP1 SURF2 TNIP1 TNPO1 TSC22D1 UPF2 VHL
Entrez ID		8848	6125
HPRD ID		07414	04699
Ensembl ID			ENSG00000122406
Uniprot IDs		A8K3Y6 Q15714	A2RUM7 B3KTM6 P46777
PDB IDs			3J3B
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Chromatin Organization Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Chromosome Organization Regulation Of Chromosome Organization Regulation Of Histone Modification Regulation Of Protein Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Methylation Histone Modification Gene Expression Cellular Nitrogen Compound Metabolic Process Peptidyl-threonine Phosphorylation RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Heterocycle Metabolic Process Regulation Of Histone Methylation Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Response To Stimulus Protein Methylation Positive Regulation Of Histone Modification Regulation Of Transcription, DNA-templated Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Signaling Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cell Communication Histone Lysine Methylation Negative Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process	Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Cytoplasmic Transport Protein Localization To Organelle Establishment Of Protein Localization To Organelle Negative Regulation Of Collateral Sprouting Ribosomal Protein Import Into Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Intracellular Protein Transport Cellular Protein Localization Viral Process Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Programmed Cell Death Intracellular Transport Cell Death Death Protein Import Into Nucleus, Translocation Cellular Localization Response To External Stimulus Protein Localization Protein Transport Establishment Of Localization In Cell Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Cellular Response To UV-C Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Vitamin B1 Negative Regulation Of Axonogenesis Chemotaxis MRNA Export From Nucleus Regulation Of MAPK Cascade Histidyl-tRNA Aminoacylation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury RNA Export From Nucleus Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Developmental Growth Spinal Cord Ventral Commissure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Growth Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?		beadchip capn13 cards cic collect conjunctival cxcl6 cytology drb5 dry entire eye ht illumina impression investigates lysozyme mini optimally optimization psca qiagen qrt qualifying rneasy severities steps taqman transcriptome	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?		beadchip capn13 cards cic collect conjunctival cxcl6 cytology drb5 dry entire eye ht illumina impression investigates lysozyme mini optimally optimization psca qiagen qrt qualifying rneasy severities steps taqman transcriptome	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?