SPOP and TP53BP1

Number of citations of the paper that reports this interaction (PubMedID 34144977)
55

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology)

		SPOP	TP53BP1
Description		speckle type BTB/POZ protein	tumor protein p53 binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity	P53 Binding DNA Binding Damaged DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Telomeric DNA Binding Histone Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin-modified Histone Reader Activity Histone H4K20me2 Reader Activity Histone Reader Activity Histone H4K20me Methyltransferase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	DNA Damage Checkpoint Signaling DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)	SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Antibody level in response to infection ( 25758998) Apolipoprotein A1 levels ( 32203549) Cardiometabolic and hematological traits ( 27668658) Eosinophil count ( 32888494) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Liver volume ( 34128465) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 27036123)
Interacting Genes		74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	60 interacting genes: ANKS1A ARAP1 ATM BCL6 BLM BRCA1 BRCA2 C10orf55 CCDC120 CCNB1 CDK1 CEBPA CHEK1 CRB2 CREB5 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AC4 H2AX H4C1 H4C14 H4C16 HGS IFI16 KAT8 KDM1A KLHDC7B LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16 OXER1 PARP1 PAXIP1 PCNT PITX1 POU6F2 PTEN RAD18 RAD50 RAD51 RBL1 RBL2 RELA SPAG9 SPOP SUMO2 TFDP1 TLX3 TP53 UBAP2 USP28 VAC14
Entrez ID		8405	7158
HPRD ID		16004	05569
Ensembl ID		ENSG00000121067	ENSG00000067369
Uniprot IDs		O43791	A6NNK5 Q12888
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT 6VA5 6VIP 7LIN 7LIO 7YQK 8EOM 8F0W 8HKW 8SVG 8SVH 8SVI 8SVJ 8SWJ 8T2D 8U4U 9CKJ
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding	Response To Ionizing Radiation Chromatin Organization Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Response Chromosome, Telomeric Region Regulation Of Cell Cycle Process Nucleoplasm Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Chromatin Remodeling Negative Regulation Of Cell Cycle DNA Repair Signal Transduction In Response To DNA Damage DNA Metabolic Process Regulation Of Cell Cycle Cellular Response To Radiation DNA Binding Response To Radiation DNA Damage Checkpoint Signaling Regulation Of DNA Recombination Cellular Response To Ionizing Radiation Protein Localization To Chromosome Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Double-strand Break Repair Telomere Organization DNA Recombination Nucleus Transcription Regulator Complex Site Of Double-strand Break Protein-containing Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Regulation Of Cell Cycle G2/M Phase Transition Response To X-ray Regulation Of Macromolecule Metabolic Process Response To Gamma Radiation Replication Fork DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Signal Transduction By P53 Class Mediator
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