SPOP and CACUL1

Number of citations of the paper that reports this interaction (PubMedID 28805822)
55

Data Source:
BioGRID (two hybrid)

		SPOP	CACUL1
Description		speckle type BTB/POZ protein	CDK2 associated cullin domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Protein Kinase Activity
Pathways		Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Anthropometric traits (multi-trait analysis) ( 30166351) Height ( 28552196) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	2 interacting genes: AR SPOP
Entrez ID		8405	143384
HPRD ID		16004	12576
Ensembl ID		ENSG00000121067	ENSG00000151893
Uniprot IDs		O43791	Q86Y37
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding	Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Nuclear Speck Androgen Binding Regulation Of Prostatic Bud Formation RNA Polymerase II General Transcription Initiation Factor Binding Cellular Response To Testosterone Stimulus Genitalia Morphogenesis Lateral Sprouting From An Epithelium Leydig Cell Differentiation Estrogen Response Element Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Differentiation Involved In Prostate Gland Development Male Sex Determination Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Morphogenesis Of An Epithelial Fold Sex Determination Organ Induction RNA Polymerase II Core Promoter Sequence-specific DNA Binding Seminiferous Tubule Development Prostate Gland Epithelium Morphogenesis Reproductive System Development Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Animal Organ Formation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase III Steroid Binding Regulation Of Animal Organ Formation Developmental Induction Molecular Function Inhibitor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epithelial Cell Morphogenesis Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Morphogenesis Of An Epithelium Response To Testosterone Regulation Of Systemic Arterial Blood Pressure Organ Growth
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