SPOP and RTN3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SPOP	RTN3
Gene Name		speckle-type POZ protein	reticulon 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Glucose Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Apoptotic Process Viral Process Vesicle-mediated Transport Endoplasmic Reticulum Tubular Network Organization
Pathways		Hedgehog 'on' state Signaling by Hedgehog
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		19 interactors: AR BRMS1 DAXX DDIT3 DPPA2 FADD GIT2 H2AFY HCST MYD88 PDX1 PIAS1 RTN3 RXRB SRRM1 TRAF1 TRAF6 UBE2E3 ZBTB16	15 interactors: CDIPT COL4A3BP FAM160A2 FGFR1 FXR2 PLEKHF2 PPP2R3C PTPN9 RAB33A RTN4 SNX1 SPOP TERF1 UGCG ZNF391
Entrez ID		8405	10313
HPRD ID		16004	18516
Ensembl ID		ENSG00000121067	ENSG00000133318
Uniprot IDs		O43791	O95197
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Intracellular Receptor Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Transcription, DNA-templated Androgen Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Transcription From RNA Polymerase II Promoter JNK Cascade RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Activation
Tagcloud ?		amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded	address affects alzheimer bace1 brains contributing deficiency deposition discernible elevation endoplasmic facilitates generating grow intriguing lasting monomer morphological negatively normally null obviously phenotypes question reticulon secretase shaping supporting tubular
Tagcloud (Difference) ?		amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded	address affects alzheimer bace1 brains contributing deficiency deposition discernible elevation endoplasmic facilitates generating grow intriguing lasting monomer morphological negatively normally null obviously phenotypes question reticulon secretase shaping supporting tubular
Tagcloud (Intersection) ?