SPOP and GCC2

Number of citations of the paper that reports this interaction (PubMedID 28805822)
55

Data Source:
BioGRID (two hybrid)

		SPOP	GCC2
Description		speckle type BTB/POZ protein	GRIP and coiled-coil domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity	Protein Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Targeting To Lysosome Protein Transport Microtubule Organizing Center Organization Protein Localization To Golgi Apparatus Microtubule Anchoring Late Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Regulation Of Protein Exit From Endoplasmic Reticulum Recycling Endosome To Golgi Transport Golgi Ribbon Formation
Pathways		Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)	Retrograde transport at the Trans-Golgi-Network Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 27863252) Platelet distribution width ( 32888494)
Interacting Genes		74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	3 interacting genes: ARL1 SPOP SRPK2
Entrez ID		8405	9648
HPRD ID		16004	11001
Ensembl ID		ENSG00000121067	ENSG00000135968
Uniprot IDs		O43791	A0A8I5QJB7 B3KR21 Q8IWJ2
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV	3BBP
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding
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