SPOP and EGLN2

Number of citations of the paper that reports this interaction (PubMedID 28089830)
46

Data Source:
BioGRID (pull down, pull down)

		SPOP	EGLN2
Description		speckle type BTB/POZ protein	egl-9 family hypoxia inducible factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity	Iron Ion Binding Protein Binding Ferrous Iron Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Cellular Response To Hypoxia
Pathways		Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Ascorbic acid Roxadustat Daprodustat Vadadustat
Diseases
GWAS		Prostate cancer ( 23535732)	Alanine aminotransferase levels ( 33547301) Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838) Chronic obstructive pulmonary disease in current smokers ( 33106845) Chronic obstructive pulmonary disease x current smoker interaction (2df) ( 33106845) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Nicotine metabolite ratio in current smokers ( 28921760) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Smoking behavior ( 20418890) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	12 interacting genes: A2M CDK2 EPAS1 ETS2 HIF1A HIF3A MFHAS1 MOB4 PRKCA SPOP SRPK2 TENT5A
Entrez ID		8405	112398
HPRD ID		16004	06970
Ensembl ID		ENSG00000121067	ENSG00000269858
Uniprot IDs		O43791	Q96KS0
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV	5V1B
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding	Intracellular Oxygen Homeostasis Angiogenesis Nuclear Speck Anatomical Structure Formation Involved In Morphogenesis Transcription Regulator Complex Regulation Of Protein Neddylation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Embryonic Placenta Development Epithelial Cell Maturation Cellular Response To Oxygen Levels Protein Dimerization Activity Positive Regulation Of Cytokine Production Involved In Inflammatory Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-serine Phosphorylation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Domain Specific Binding Chromatin Regulation Of RNA Metabolic Process Transcription Coactivator Binding Positive Regulation Of Macromolecule Biosynthetic Process Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Phosphorylation Positive Regulation Of Chromatin Organization Protein Serine Kinase Activity Nucleoplasm Regulation Of Primary Metabolic Process Protein Phosphorylation Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Tissue Remodeling Response To Hypoxia Response To Oxygen Levels Response To Oxidative Stress Response To Decreased Oxygen Levels DNA-binding Transcription Factor Activity Erythrocyte Differentiation Cis-regulatory Region Sequence-specific DNA Binding Myoblast Fate Commitment Ectodermal Cell Fate Commitment
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