SPOP and GATAD2A

Number of citations of the paper that reports this interaction (PubMedID 29996942)
39

Data Source:
BioGRID (two hybrid)

		SPOP	GATAD2A
Description		speckle type BTB/POZ protein	GATA zinc finger domain containing 2A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Chromosome NuRD Complex Nuclear Speck
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation
Pathways		Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cirrhosis (alcohol related) ( 32853455) Height ( 31562340 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mild age-related type 2 diabetes ( 34737425) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Serum metabolite levels ( 33031748) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	15 interacting genes: CBFA2T3 CEBPA CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 PAK4 SPOP
Entrez ID		8405	54815
HPRD ID		16004	11741
Ensembl ID		ENSG00000121067	ENSG00000167491
Uniprot IDs		O43791	Q86YP4
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV	2L2L
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding	Chromatin Remodeling Chromatin Organization N-terminal Peptidyl-lysine Acetylation Structural Constituent Of Chromatin Nucleosome Chromosome Response To Nutrient Levels Epigenetic Regulation Of Gene Expression Response To Bisphenol A Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Intermediate Filament Organization Ventricular Cardiac Muscle Tissue Development Regulation Of DNA Repair Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process NuRD Complex Acetyltransferase Activity Protein-containing Complex Nucleosome Assembly Hematopoietic Stem Cell Proliferation Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Methyl-CpG Binding Nucleosome Organization Granulocyte Differentiation Positive Regulation Of DNA Repair Histone Acetyltransferase Activity Heterochromatin Formation Protein Acetylation DNA Methylation-dependent Constitutive Heterochromatin Formation Intermediate Filament Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Embryonic Organ Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Nucleosomal DNA Binding Inositol-3-phosphate Synthase Activity Nucleoplasm DNA-binding Transcription Factor Binding Structural Molecule Activity Protein-DNA Complex Assembly Heterochromatin Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Glycolytic Process Response To Vitamin B2
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?