UBR5 and UBE2B

Number of citations of the paper that reports this interaction (PubMedID 11714696)
0

Data Source:
BioGRID (pull down)

		UBR5	UBE2B
Description		ubiquitin protein ligase E3 component n-recognin 5	ubiquitin conjugating enzyme E2 B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane Membrane HULC Complex
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination DNA Repair DNA Damage Response Response To Oxidative Stress Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Estrogen Receptor Signaling Pathway Heterochromatin Boundary Formation Protein K29-linked Ubiquitination Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway Retinoic Acid Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Canonical Wnt Signaling Pathway Cytoplasm Protein Quality Control DNA Repair-dependent Chromatin Remodeling Protein Branched Polyubiquitination	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spermatogenesis Sperm Axoneme Assembly Response To Xenobiotic Stimulus Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Negative Regulation Of Developmental Process Protein Autoubiquitination Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Reproductive Process
Pathways			Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)	Relative amplitude of rest-activity cycles ( 30120083)
Interacting Genes		53 interacting genes: ACSL4 AKIRIN2 ATF3 BARD1 CDC20 CEBPA CIB1 CIP2A CSPP1 DYRK2 ERG ESR1 GSK3B INO80C KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NFIL3 NR1I2 NR3C1 NRL OTUD5 PAIP1 PAIP2 PCK1 PGR PPP1CA PTTG1 RARA RUVBL2 RXRA SATB1 SMAD2 SMARCB1 SOX2 STIP1 TCEA1 TOPBP1 TXNIP UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2J1 UBE2L3 UBE3A VDR	29 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 H2BC1 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF167 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBA6 UBR1 UBR2 UBR3 UBR4 UBR5 UNC119
Entrez ID		51366	7320
HPRD ID		06436	01533
Ensembl ID		ENSG00000104517	ENSG00000119048
Uniprot IDs		O95071	P63146
PDB IDs		1I2T 2QHO 3PT3 8BJA 8C06 8C07 8D4X 8E0Q 8EWI 8P82 8P83	1JAS 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Chromatin Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Response To Lipid Protein K48-linked Ubiquitination Negative Regulation Of RNA Metabolic Process Cellular Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Modification Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Proteolysis	Ubiquitin Protein Ligase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Zinc Ion Binding Transferase Activity Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein K29-linked Ubiquitination Metal Ion Binding Cellular Response To Stress Protein Autoubiquitination Protein K63-linked Ubiquitination Ubiquitin Activating Enzyme Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Ubiquitin Protein Ligase Binding Protein K6-linked Ubiquitination Response To Stress Cytoplasm Protein Quality Control Protein-containing Complex Binding HULC Complex DNA Damage Response Response To Amino Acid Positive Regulation Of Metabolic Process Placenta Development L-leucine Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Epithelial Cell Proliferation Involved In Prostate Gland Development Limb Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ubiquitin-like Modifier Activating Enzyme Activity T Follicular Helper Cell Differentiation
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