UBR5 and UBE2L3

Number of citations of the paper that reports this interaction (PMID 11714696)
31

Data Source:
BioGRID (pull down)

		UBR5	UBE2L3
Gene Name		ubiquitin protein ligase E3 component n-recognin 5	ubiquitin-conjugating enzyme E2L 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Catenin Import Into Nucleus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Progesterone Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Protein Polyubiquitination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) HDL cholesterol ( 20686565) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 21408207 19838193)
Protein-Protein Interactions		23 interactors: BARD1 CIB1 DYRK2 GSK3B KPNA1 KPNA2 KPNB1 MAPK1 NR1I2 PAIP1 PAIP2 PGR SATB1 SMAD2 TCEA1 TOPBP1 TP53 UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3	64 interactors: ARIH1 ARIH2 ATXN3 BRCA1 CBL CBLC CCNB1IP1 CUL9 DTX3 FBXO2 FOS HACE1 HERC3 HSPA4 HUWE1 ITCH LIG4 MAPK6 MDM2 MID1 MKRN3 MUL1 NEDD4 NEDD4L NFKBIA NR3C1 PARK2 PJA1 POLR2A PTEN RAD23A RBCK1 RBX1 RELA RNF103 RNF113B RNF125 RNF144A RNF144B RNF19A RNF2 RNF216 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TRAF6 TRAF7 TRIM21 TRIM28 TRIM39 TRIP12 UBA1 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR5 WWP1 WWP2
Entrez ID		51366	7332
HPRD ID		06436	04762
Ensembl ID		ENSG00000104517	ENSG00000185651
Uniprot IDs		E7EMW7 O95071	P68036
PDB IDs		1I2T 2QHO 3PT3	1C4Z 1FBV 3SQV 3SY2
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Cellular Response To Stress Protein Polyubiquitination DNA Repair Cellular Response To Stimulus Protein K11-linked Ubiquitination Response To Organic Substance Apoptotic Process Programmed Cell Death Cell Death Death Response To Stimulus Viral Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nucleocytoplasmic Transport Regulation Of Intracellular Transport Nuclear Transport Negative Regulation Of Gene Expression Protein Import Positive Regulation Of Metabolic Process Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Toll-like Receptor 3 Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Ubiquitination Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Growth Factor NLS-bearing Protein Import Into Nucleus Toll-like Receptor 4 Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Polyubiquitination Proteolysis Protein Metabolic Process Catabolic Process Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Viral Process Regulation Of Protein Catabolic Process Cellular Response To Organic Substance Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Protein K48-linked Ubiquitination Negative Regulation Of Signaling Protein Monoubiquitination Cellular Response To Stress Metabolic Process Protein Autoubiquitination Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Organic Substance Response To Growth Factor Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cytokine Production Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Positive Regulation Of Protein Catabolic Process
Tagcloud ?		aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities	2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Difference) ?		aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities	2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Intersection) ?