UBR5 and UBE2A

Number of citations of the paper that reports this interaction (PMID 11714696)
31

Data Source:
BioGRID (pull down)

		UBR5	UBE2A
Gene Name		ubiquitin protein ligase E3 component n-recognin 5	ubiquitin-conjugating enzyme E2A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Chromatin Nuclear Chromatin XY Body Cytoplasm Cytosol HULC Complex
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Catenin Import Into Nucleus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Progesterone Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Protein Polyubiquitination In Utero Embryonic Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Proliferation Response To UV Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Brain connectivity ( 23471985)
Protein-Protein Interactions		23 interactors: BARD1 CIB1 DYRK2 GSK3B KPNA1 KPNA2 KPNB1 MAPK1 NR1I2 PAIP1 PAIP2 PGR SATB1 SMAD2 TCEA1 TOPBP1 TP53 UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3	20 interactors: CDK1 CDK2 CDK9 CDKN2A CRMP1 HIST2H2BE HLTF MDM2 PCNA RAD18 RNF20 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2
Entrez ID		51366	7319
HPRD ID		06436	02422
Ensembl ID		ENSG00000104517	ENSG00000077721
Uniprot IDs		E7EMW7 O95071	P49459
PDB IDs		1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Cellular Response To Stress Protein Polyubiquitination DNA Repair Cellular Response To Stimulus Protein K11-linked Ubiquitination Response To Organic Substance Apoptotic Process Programmed Cell Death Cell Death Death Response To Stimulus Viral Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nucleocytoplasmic Transport Regulation Of Intracellular Transport Nuclear Transport Negative Regulation Of Gene Expression Protein Import Positive Regulation Of Metabolic Process Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Toll-like Receptor 3 Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Ubiquitination Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Growth Factor NLS-bearing Protein Import Into Nucleus Toll-like Receptor 4 Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Cell Cycle Arrest DNA Repair Chromosome Organization Regulation Of DNA Replication Chromatin Organization Protein Polyubiquitination Response To Stress Positive Regulation Of Cell Cycle Arrest Catabolic Process Cellular Protein Metabolic Process Ras Protein Signal Transduction Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Proteolysis Positive Regulation Of Cell Cycle Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Response To Stimulus Regulation Of Signal Transduction By P53 Class Mediator Chromatin Modification DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Positive Regulation Of Cell Aging Organelle Organization Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Cellular Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint DNA Packaging Signal Transduction Involved In Cell Cycle Checkpoint
Tagcloud ?		aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities	11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring
Tagcloud (Difference) ?		aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities	11p15 angular autism connections connectivity connectome corrections discover enforced genetics gwass heritability know macrod2 matrices milder organizational posthoc replicated retardation rs2618516 scanned spon1 stringent subsample topological twin twins wiring
Tagcloud (Intersection) ?