UBR5 and ACSL4

Number of citations of the paper that reports this interaction (PubMedID 37428466)
49

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		UBR5	ACSL4
Description		ubiquitin protein ligase E3 component n-recognin 5	acyl-CoA synthetase long chain family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Plasma Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Ligase Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair DNA Damage Response Response To Oxidative Stress Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Estrogen Receptor Signaling Pathway Heterochromatin Boundary Formation Protein K29-linked Ubiquitination Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway Retinoic Acid Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Canonical Wnt Signaling Pathway Cytoplasm Protein Quality Control DNA Repair-dependent Chromatin Remodeling Protein Branched Polyubiquitination	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Lipid Biosynthetic Process Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Negative Regulation Of Prostaglandin Secretion Long-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Embryonic Process Involved In Female Pregnancy Fatty Acid Derivative Biosynthetic Process
Pathways			Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs
Drugs			Icosapent Troglitazone Rosiglitazone
Diseases			Non-syndromic X-linked mental retardation
GWAS		Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)	Mean platelet volume ( 32888494)
Interacting Genes		53 interacting genes: ACSL4 AKIRIN2 ATF3 BARD1 CDC20 CEBPA CIB1 CIP2A CSPP1 DYRK2 ERG ESR1 GSK3B INO80C KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NFIL3 NR1I2 NR3C1 NRL OTUD5 PAIP1 PAIP2 PCK1 PGR PPP1CA PTTG1 RARA RUVBL2 RXRA SATB1 SMAD2 SMARCB1 SOX2 STIP1 TCEA1 TOPBP1 TXNIP UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2J1 UBE2L3 UBE3A VDR	7 interacting genes: APP CDK1 DSE HTATIP2 PRKCB UBR5 YWHAQ
Entrez ID		51366	2182
HPRD ID		06436	02152
Ensembl ID		ENSG00000104517	ENSG00000068366
Uniprot IDs		O95071	O60488 Q8TAF6
PDB IDs		1I2T 2QHO 3PT3 8BJA 8C06 8C07 8D4X 8E0Q 8EWI 8P82 8P83
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Chromatin Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Response To Lipid Protein K48-linked Ubiquitination Negative Regulation Of RNA Metabolic Process Cellular Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Modification Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Proteolysis	Positive Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Protein Transport Positive Regulation Of Protein Localization Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Chromatin Remodeling Response To Copper Ion Positive Regulation Of Protein Import Into Nucleus Regulation Of Transport Chromatin Organization Protein Metabolic Process Positive Regulation Of Transport Nuclear Membrane Organization Intracellular Signal Transduction Regulation Of Protein Localization Protein Phosphorylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Pronuclear Fusion Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Protein Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Chromatin Binding Positive Regulation Of Protein Import Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Protein Localization To Nucleus Histone H3T6 Kinase Activity Chondroitin-glucuronate 5-epimerase Activity Heterochromatin Boundary Formation PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium
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