UBR5 and PAIP2

Number of citations of the paper that reports this interaction (PMID 16601676)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		UBR5	PAIP2
Gene Name		ubiquitin protein ligase E3 component n-recognin 5	poly(A) binding protein interacting protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Cytoplasm
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding	MRNA Binding Protein Binding Translation Repressor Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Catenin Import Into Nucleus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Progesterone Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Spermatogenesis Memory Negative Regulation Of Translational Initiation Regulation Of Long-term Synaptic Potentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: BARD1 CIB1 DYRK2 GSK3B KPNA1 KPNA2 KPNB1 MAPK1 NR1I2 PAIP1 PAIP2 PGR SATB1 SMAD2 TCEA1 TOPBP1 TP53 UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3	5 interactors: APP ELAVL1 PABPC1 RPL11 UBR5
Entrez ID		51366	51247
HPRD ID		06436	05726
Ensembl ID		ENSG00000104517	ENSG00000120727
Uniprot IDs		E7EMW7 O95071	Q9BPZ3
PDB IDs		1I2T 2QHO 3PT3	1JGN 3KUS 3KUT
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Cellular Response To Stress Protein Polyubiquitination DNA Repair Cellular Response To Stimulus Protein K11-linked Ubiquitination Response To Organic Substance Apoptotic Process Programmed Cell Death Cell Death Death Response To Stimulus Viral Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nucleocytoplasmic Transport Regulation Of Intracellular Transport Nuclear Transport Negative Regulation Of Gene Expression Protein Import Positive Regulation Of Metabolic Process Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Toll-like Receptor 3 Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Ubiquitination Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Growth Factor NLS-bearing Protein Import Into Nucleus Toll-like Receptor 4 Signaling Pathway	MRNA Stabilization MRNA Polyadenylation Regulation Of Translation RNA Polyadenylation Regulation Of MRNA Stability Regulation Of RNA Stability Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Translation MRNA Metabolic Process MRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Synaptic Growth At Neuromuscular Junction MRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Catabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Histone H2A K63-linked Ubiquitination Intracellular Receptor Signaling Pathway Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translational Initiation Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein K63-linked Ubiquitination Progesterone Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Neuron Remodeling Gene Expression 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Cellular Biosynthetic Process MRNA Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Aromatic Compound Catabolic Process Regulation Of MRNA 3'-end Processing
Tagcloud ?		aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities	5l avian bicistronic bona closed compatible concomitantly explanation fide herpesvirus ie immediate ires leader manners marek mdv1 message micrornas mutagenesis neurovirulence pabp1 poly pool pp14 recruitment ribosome serotype virally
Tagcloud (Difference) ?		aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities	5l avian bicistronic bona closed compatible concomitantly explanation fide herpesvirus ie immediate ires leader manners marek mdv1 message micrornas mutagenesis neurovirulence pabp1 poly pool pp14 recruitment ribosome serotype virally
Tagcloud (Intersection) ?