UBR5 and KPNB1

Number of citations of the paper that reports this interaction (PubMedID 12011095)
0

Data Source:
HPRD (in vitro)

		UBR5	KPNB1
Description		ubiquitin protein ligase E3 component n-recognin 5	karyopherin subunit beta 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Membrane Protein-containing Complex Specific Granule Lumen NLS-dependent Protein Nuclear Import Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Small GTPase Binding Hsp90 Protein Binding Nuclear Import Signal Receptor Activity Importin-alpha Family Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair DNA Damage Response Response To Oxidative Stress Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Estrogen Receptor Signaling Pathway Heterochromatin Boundary Formation Protein K29-linked Ubiquitination Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway Retinoic Acid Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Canonical Wnt Signaling Pathway Cytoplasm Protein Quality Control DNA Repair-dependent Chromatin Remodeling Protein Branched Polyubiquitination	RNA Import Into Nucleus Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Protein Transport Astral Microtubule Organization Positive Regulation Of Hippo Signaling Establishment Of Mitotic Spindle Localization Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription Mitotic Spindle Assembly
Pathways			ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production SARS-CoV-1 activates/modulates innate immune responses Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)	Asthma ( 31619474) Body mass index ( 26426971) Glycine levels ( 30837465) HDL cholesterol ( 30275531) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 22190364) Optic cup area ( 25631615) Simvastatin-induced myopathy ( 31220337) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		53 interacting genes: ACSL4 AKIRIN2 ATF3 BARD1 CDC20 CEBPA CIB1 CIP2A CSPP1 DYRK2 ERG ESR1 GSK3B INO80C KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NFIL3 NR1I2 NR3C1 NRL OTUD5 PAIP1 PAIP2 PCK1 PGR PPP1CA PTTG1 RARA RUVBL2 RXRA SATB1 SMAD2 SMARCB1 SOX2 STIP1 TCEA1 TOPBP1 TXNIP UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2J1 UBE2L3 UBE3A VDR	75 interacting genes: AMFR CCNB1 CCNE1 CD99 CDC25C CEBPA CHD3 CRBN CSE1L CSNK1A1 CUL4B DSCAM ELAVL1 EPAS1 EXO1 FGFR1 H1-0 H1-2 IGFBP3 IGFBP5 IPO7 IPO8 ITCH KPNA1 KPNA2 KPNA3 KPNA6 LBR LINC01554 LYST MESD MSL1 MTNR1A NFATC1 NFYA NOSIP NUP153 NUP50 NUP54 NUP62 NUP98 OGT PIAS4 PLCD1 PRKD3 PTEN PTHLH PTMA PTN PTPN2 RAN RANBP2 RANBP3 RBX1 RNF10 RPL5 RUNX1T1 SELENOS SENP2 SMAD2 SMAD3 SMN1 SMNDC1 SNAI1 SNAPIN SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5
Entrez ID		51366	3837
HPRD ID		06436	04114
Ensembl ID		ENSG00000104517	ENSG00000108424
Uniprot IDs		O95071	B7Z752 Q14974
PDB IDs		1I2T 2QHO 3PT3 8BJA 8C06 8C07 8D4X 8E0Q 8EWI 8P82 8P83	1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89 8GCN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Chromatin Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Response To Lipid Protein K48-linked Ubiquitination Negative Regulation Of RNA Metabolic Process Cellular Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Modification Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Proteolysis	Protein Import Into Nucleus Import Into Nucleus Nucleoplasm Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Transport Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process NLS-dependent Protein Nuclear Import Complex Viral Penetration Into Host Nucleus Nuclear Localization Sequence Binding Establishment Of Protein Localization Intracellular Protein Localization NLS-bearing Protein Import Into Nucleus Positive Regulation Of RNA Metabolic Process Nuclear Envelope Intracellular Transport Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Cellular Localization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Transport Nuclear Import Signal Receptor Activity Intracellular Transport Of Virus Regulation Of Macromolecule Metabolic Process Host Cell Cytoplasm Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Nuclear Membrane Protein Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Transport Establishment Of Localization In Cell Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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