SCAMP3 and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		SCAMP3	DNAJC5
Description		secretory carrier membrane protein 3	DnaJ heat shock protein family (Hsp40) member C5
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Trans-Golgi Network Membrane Recycling Endosome Membrane Extracellular Exosome	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	Ubiquitin Protein Ligase Binding	Protein Binding ATP-dependent Protein Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Protein Transport	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways			Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		10 interacting genes: APP DNAJC5 EGFR HGS NEDD4 NEDD4L TSG101 WWOX WWP2 YAP1	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		10067	80331
HPRD ID		06074	08539
Ensembl ID		ENSG00000116521	ENSG00000101152
Uniprot IDs		A0AAQ5BHM9 A0AAQ5BHP8 A0AAQ5BHR7 A0AAQ5BHS3 O14828	Q9H3Z4
PDB IDs			2N04 2N05
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Regulation Of Protein Catabolic Process Early Endosome Membrane Regulation Of Protein Localization Regulation Of Transport Establishment Of Protein Localization To Vacuole Regulation Of Potassium Ion Transmembrane Transport Regulation Of Vesicle-mediated Transport Cytosol Sodium Channel Inhibitor Activity Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Growth Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Vesicle-mediated Transport Protein Localization To Vacuole Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Monoatomic Ion Transport Ubiquitin Binding Negative Regulation Of Sodium Ion Transport Regulation Of Signal Transduction Regulation Of Metal Ion Transport Positive Regulation Of Exosomal Secretion Endosome Negative Regulation Of Transmembrane Transport Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Macromolecule Metabolic Process Lysosomal Transport Proline-rich Region Binding Enzyme Binding Positive Regulation Of Transport Receptor Catabolic Process Regulation Of Exosomal Secretion Regulation Of Cell Growth Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Membrane Potential	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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