SCNN1A and SCNN1G

Number of citations: 0 (PubMedID 10409621)
Data Source: HPRD (in vivo)

		SCNN1A	SCNN1G
Name		sodium channel epithelial 1 subunit alpha	sodium channel epithelial 1 subunit gamma
Structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Cilium External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Motile Cilium Sodium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Sperm Principal Piece	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Exosome
	Molecular Function	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Monoatomic Ion Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Sodium Ion Homeostasis Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin	Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Sodium Ion Homeostasis Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		Stimuli-sensing channels Sensory perception of salty taste	Stimuli-sensing channels Sensory perception of salty taste
Drugs		Triamterene Amiloride	Triamterene Amiloride
Diseases		Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)	Liddle syndrome Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Adverse response to drug ( 30420678 ) Alopecia areata ( 25608926 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Obesity (early onset extreme) ( 23563609 ) Primary biliary cirrhosis ( 22961000 ) Spleen volume ( 34128465 )	Heel bone mineral density ( 30598549 ) Parent of origin effect on receptive language ability (paternal) ( 32635940 )
Interacting Genes		17 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2	13 interacting genes: COMMD10 EPN1 MAPK1 NEDD4 NEDD4L SCNN1A SCNN1B SCNN1D SERP1 SOX4 STX1A USP10 WWP2
Entrez ID		6337	6340
HPRD ID		02575	02862
Ensembl ID		ENSG00000111319	ENSG00000166828
Uniprot IDs		P37088	A5X2V1 P51170
PDB IDs		2M3O 6BQN 6WTH	6BQN 6WTH 9BLR 9BTG 9BTU
GO Terms Enriched among Interactors		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Post-translational Protein Modification Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Potassium Ion Export Across Plasma Membrane Transmembrane Transporter Binding Protein Monoubiquitination Proteolysis Ubiquitin Protein Ligase Activity Protein Modification Process Negative Regulation Of Potassium Ion Transmembrane Transport Protein Ubiquitination Import Into Cell Sodium Ion Import Across Plasma Membrane Protein Metabolic Process Negative Regulation Of Potassium Ion Transport Catabolic Process Sensory Perception Of Salty Taste Extracellular Exosome Macromolecule Metabolic Process Biological Process Involved In Interaction With Host Cellular Response To Aldosterone Sodium Channel Complex Protein Catabolic Process Sodium Channel Inhibitor Activity Sensory Perception Of Sour Taste Cellular Response To Vasopressin Regulation Of Protein Catabolic Process Sodium Ion Transport Establishment Of Protein Localization To Vacuole Regulation Of Dendrite Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Receptor Internalization Positive Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Protein Transport Endocytosis Endosome Negative Regulation Of Sodium Ion Transport	Import Into Cell Sodium Ion Import Across Plasma Membrane Sensory Perception Of Salty Taste Negative Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Aldosterone Sodium Channel Complex Sensory Perception Of Sour Taste Cellular Response To Vasopressin Transmembrane Transporter Binding Potassium Channel Inhibitor Activity Regulation Of Biological Quality Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Sodium Ion Transport Response To Aldosterone Cellular Response To Acidic PH Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Sodium Ion Homeostasis Inorganic Cation Import Across Plasma Membrane Response To Acidic PH Cellular Response To PH Negative Regulation Of Potassium Ion Transport Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Transmembrane Transport Sodium Ion Homeostasis Response To Mineralocorticoid Response To PH Import Across Plasma Membrane Protein Monoubiquitination Endocytosis Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Chemical Homeostasis Cellular Response To Steroid Hormone Stimulus Regulation Of Potassium Ion Transport Negative Regulation Of Sodium Ion Transport Metal Ion Transport Negative Regulation Of Monoatomic Ion Transport Regulation Of Transport Protein Modification Process Sensory Perception Of Chemical Stimulus Cellular Homeostasis Negative Regulation Of Transmembrane Transport Receptor Catabolic Process Protein Modification By Small Protein Conjugation