COPA and SCYL1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (pull down, affinity chromatography technology, biochemical)

		COPA	SCYL1
Description		coat protein complex I subunit alpha	SCY1 like pseudokinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Growth Cone COPI-coated Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Centrosome Cytosol Cytoskeleton Membrane COPI Vesicle Coat
	Molecular Function	MRNA Binding Hormone Activity Structural Molecule Activity Protein Binding	DNA Binding Protein Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Signal Transduction Protein Transport Vesicle-mediated Transport Pancreatic Juice Secretion Protein Localization To Axon Protein Localization To Cell Leading Edge	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Inflammatory Response Intracellular Protein Localization Vesicle-mediated Transport Spinal Cord Motor Neuron Differentiation Neuron Development
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs			Grn163l
Diseases
GWAS		Breast size ( 27182965)	Acne (severe) ( 24927181) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femoral neck bone mineral density ( 22504420) Hip index ( 34021172) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946)
Interacting Genes		21 interacting genes: ARCN1 ARFGAP1 CDC42 COPB2 COPE DUX4 HUNK MTNR1B PDGFRB PTEN RBM11 RUNX1 SACM1L SCYL1 SLC25A11 STX8 SUMO2 TMED10 TMED2 WBP1 WBP2	21 interacting genes: APP ARF1 ARF3 AXIN1 CCNF CD93 CDC25A CHD1L COIL COPA COPE DAPK1 DDX6 GORAB LENG1 NOD2 PIN1 PLEKHF2 SMURF1 SNCA TCEA2
Entrez ID		1314	57410
HPRD ID		03564	06414
Ensembl ID		ENSG00000122218	ENSG00000142186
Uniprot IDs		P53621	E9PK59 E9PPN3 Q96KG9
PDB IDs		6PBG 6TZT 6U3V
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Golgi Membrane Golgi Vesicle Transport Golgi Apparatus COPI Coating Of Golgi Vesicle Establishment Of Protein Localization Golgi Localization Intracellular Protein Localization Phosphatidylinositol-3-phosphate Phosphatase Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum Membrane Cell Migration Involved In Heart Development Zymogen Granule Membrane Protein Transport Dendritic Spine Morphogenesis Cytoplasmic Vesicle Intracellular Transport Intracellular Protein Transport Golgi Organization Phosphatidylinositol Dephosphorylation COPII Vesicle Coating Vesicle Cargo Loading Dendritic Spine Organization Intra-Golgi Vesicle-mediated Transport Membrane Organization Phospholipid Dephosphorylation COPII-coated ER To Golgi Transport Vesicle Vesicle Coating Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Negative Regulation Of Synaptic Vesicle Clustering Oxoglutarate:malate Antiporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Neuron Projection Organization Postsynapse Organization Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Syntaxin Binding Cerebellar Purkinje Cell Layer Maturation GBD Domain Binding Storage Vacuole	Positive Regulation Of Catabolic Process Intracellular Transport Regulation Of Protein Metabolic Process Vesicle-mediated Transport Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Macrophage Activation Protein Localization To Axon Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Protein Domain Specific Binding COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat I-SMAD Binding Positive Regulation Of JNK Cascade Cellular Localization Regulation Of Neurotransmitter Uptake Copper Ion Homeostasis Transport Vesicle Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cytoplasmic Vesicle R-SMAD Binding Myeloid Leukocyte Activation Amyloid Fibril Formation Establishment Of Protein Localization Growth Cone Microglial Cell Activation Negative Regulation Of Protein Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Golgi Apparatus Mitotic Cleavage Furrow Ingression Intra-Golgi Vesicle-mediated Transport DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cis-trans Isomerase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?