COPA and MTNR1B

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
HPRD (in vivo)

		COPA	MTNR1B
Gene Name		coatomer protein complex, subunit alpha	melatonin receptor 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Membrane COPI Vesicle Coat Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Structural Molecule Activity	G-protein Coupled Receptor Activity Protein Binding Melatonin Receptor Activity
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Pancreatic Juice Secretion COPI Coating Of Golgi Vesicle Membrane Organization	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Glucose Homeostasis Regulation Of Insulin Secretion
Pathways		COPI Mediated Transport Golgi to ER Retrograde Transport	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS			Adverse response to radiation therapy ( 23719583) Diabetes (gestational) ( 22233651) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907 19060909 19651812 22508271) Glycated hemoglobin levels ( 20858683) Glycemic traits ( 23575436) Insomnia (caffeine-induced) ( 22754043) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Obesity-related traits ( 23251661) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		12 interactors: ARCN1 ARFGAP1 COPB2 COPE COPZ1 MTNR1B PDGFRB SACM1L SLC25A11 STX8 TMED10 TMED2	20 interactors: CANX COPA CTNND1 FLNA GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 ITM2C MTNR1A PDIA6 PI4KA PPM1G VPS35 YWHAQ
Entrez ID		1314	4544
HPRD ID		03564	02882
Ensembl ID		ENSG00000122218	ENSG00000134640
Uniprot IDs		P53621	P49286
PDB IDs
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Membrane Budding Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Organization Establishment Of Vesicle Localization Vesicle Localization Golgi Vesicle Transport Establishment Of Organelle Localization Organelle Localization Membrane Organization Protein Transport Vesicle-mediated Transport Intracellular Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Cellular Protein Localization Organelle Organization Intra-Golgi Vesicle-mediated Transport Cellular Localization Cargo Loading Into Vesicle ER To Golgi Vesicle-mediated Transport COPII Vesicle Coating COPII-coated Vesicle Budding Transport Cytoplasmic Transport Cell Migration Involved In Coronary Angiogenesis Cerebellar Purkinje Cell Layer Maturation Metanephric Mesenchymal Cell Migration Golgi Organization Angiogenesis Involved In Coronary Vascular Morphogenesis Cell Migration Involved In Kidney Development Alpha-ketoglutarate Transport Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Smooth Muscle Cell Chemotaxis Cerebellum Maturation Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Cell Migration Involved In Vasculogenesis Metanephric S-shaped Body Morphogenesis Glomerular Mesangial Cell Proliferation Positive Regulation Of Metanephric Mesenchymal Cell Migration Comma-shaped Body Morphogenesis	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Signaling Cell Communication Substantia Nigra Development Signal Transduction Wound Healing Vesicle-mediated Transport Neural Nucleus Development Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Stimulus Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stimulus Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Glucagon Stimulus Negative Regulation Of Nucleotide Metabolic Process Membrane Organization Response To Peptide Vesicle Organization Vesicle Fusion Regulation Of Protein Folding In Endoplasmic Reticulum Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Glucagon Positive Regulation Of Nuclease Activity Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Cyclase Activity Platelet Degranulation Secretion Cerebellum Structural Organization Negative Regulation Of Late Endosome To Lysosome Transport Organelle Fusion Cellular Response To Peptide Hormone Stimulus
Tagcloud ?		atpases cgr cognate copb copper copz copz1 copz2 corynebacterium csor derepression efflux encode exporter glutamicum implied lacz metallochaperone monocistronic multilayered nickel operon redundant regulon repressor talk uniquely zinc zur	china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Difference) ?		atpases cgr cognate copb copper copz copz1 copz2 corynebacterium csor derepression efflux encode exporter glutamicum implied lacz metallochaperone monocistronic multilayered nickel operon redundant regulon repressor talk uniquely zinc zur	china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Intersection) ?