COPA and STX8

Number of citations of the paper that reports this interaction (PubMedID 12388752)
54

Data Source:
HPRD (in vivo)

		COPA	STX8
Description		coat protein complex I subunit alpha	syntaxin 8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Growth Cone COPI-coated Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome	Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Plasma Membrane Endomembrane System Membrane SNARE Complex Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	MRNA Binding Hormone Activity Structural Molecule Activity Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Signal Transduction Protein Transport Vesicle-mediated Transport Pancreatic Juice Secretion Protein Localization To Axon Protein Localization To Cell Leading Edge	Intracellular Protein Transport Vesicle Fusion Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Type II Interferon Regulation Of Protein Localization To Plasma Membrane
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Breast size ( 27182965)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		21 interacting genes: ARCN1 ARFGAP1 CDC42 COPB2 COPE DUX4 HUNK MTNR1B PDGFRB PTEN RBM11 RUNX1 SACM1L SCYL1 SLC25A11 STX8 SUMO2 TMED10 TMED2 WBP1 WBP2	84 interacting genes: ACVR1 AMIGO1 AQP2 AQP6 ARL13B ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SLC35H1 SSMEM1 STAR STMN4 STX1A STX2 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VPS11 VPS18 VTI1B WDR91
Entrez ID		1314	9482
HPRD ID		03564	05012
Ensembl ID		ENSG00000122218	ENSG00000170310
Uniprot IDs		P53621	Q9UNK0
PDB IDs		6PBG 6TZT 6U3V
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Golgi Membrane Golgi Vesicle Transport Golgi Apparatus COPI Coating Of Golgi Vesicle Establishment Of Protein Localization Golgi Localization Intracellular Protein Localization Phosphatidylinositol-3-phosphate Phosphatase Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum Membrane Cell Migration Involved In Heart Development Zymogen Granule Membrane Protein Transport Dendritic Spine Morphogenesis Cytoplasmic Vesicle Intracellular Transport Intracellular Protein Transport Golgi Organization Phosphatidylinositol Dephosphorylation COPII Vesicle Coating Vesicle Cargo Loading Dendritic Spine Organization Intra-Golgi Vesicle-mediated Transport Membrane Organization Phospholipid Dephosphorylation COPII-coated ER To Golgi Transport Vesicle Vesicle Coating Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Negative Regulation Of Synaptic Vesicle Clustering Oxoglutarate:malate Antiporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Neuron Projection Organization Postsynapse Organization Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Syntaxin Binding Cerebellar Purkinje Cell Layer Maturation GBD Domain Binding Storage Vacuole	Membrane Syntaxin Binding Endoplasmic Reticulum Membrane SNARE Binding Membrane Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Docking Protein Binding Vesicle Docking Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Protein Transport Organelle Fusion Chloride Channel Inhibitor Activity Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Endomembrane System SNARE Complex Disassembly Soluble NSF Attachment Protein Activity Membrane Organization Transmembrane Transport Cellular Localization Endoplasmic Reticulum Neurotransmitter Transport Neurotransmitter Reuptake Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutathione Peroxidase Activity Establishment Of Protein Localization Intracellular Transport Transforming Growth Factor Beta Receptor Activity, Type I Leukotriene-C4 Synthase Activity Protein Transport Presynaptic Active Zone Membrane Norepinephrine Uptake Neurotransmitter Uptake Plasma Membrane Golgi Vesicle Transport Activin Receptor Complex Activin Receptor Activity, Type I CORVET Complex Lysosomal Membrane Renal Water Transport Voltage-gated Potassium Channel Complex Serotonin Uptake Norepinephrine Transport Protein-containing Complex Disassembly
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