EHD1 and CLTC

Number of citations of the paper that reports this interaction (PMID 11423532)
33

Data Source:
BioGRID (pull down)

		EHD1	CLTC
Gene Name		EH-domain containing 1	clathrin, heavy chain (Hc)
Image
Gene Ontology Annotations	Cellular Component	Lipid Particle Plasma Membrane Endosome Membrane Membrane Platelet Dense Tubular Network Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Vesicular Exosome	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex
	Molecular Function	Calcium Ion Binding Protein Binding ATP Binding GTP Binding Rab GTPase Binding	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Cholesterol Storage Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Factors involved in megakaryocyte development and platelet production	Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ANKFY1 AP2A1 CLTC EHBP1 EHD3 IGF1R MICAL1 MICALL1 PLA2G4A RAB11FIP2 RBSN SNAP29	60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		10938	1213
HPRD ID		09325	00350
Ensembl ID		ENSG00000110047	ENSG00000141367
Uniprot IDs		B2R5U3 Q9H4M9	Q00610
PDB IDs		2JQ6 2KFF 2KFG 2KFH 2KSP	2XZG 4G55
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Negative Regulation Of Hyaluronan Biosynthetic Process Endosomal Transport Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Cellular Localization Membrane Organization Endocytic Recycling Protein Localization Endocytosis Transport Golgi Vesicle Transport Intracellular Transport Vesicle Fusion Receptor-mediated Endocytosis Intracellular Protein Transport Inactivation Of MAPKK Activity Slow Endocytic Recycling Organelle Fusion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Cell Polarity Endosomal Vesicle Fusion Golgi To Lysosome Transport Positive Regulation Of Pinocytosis Membrane Fusion Regulation Of Body Fluid Levels Cellular Protein Localization Platelet Activating Factor Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Secretion Protein Targeting To Membrane Platelet Activating Factor Metabolic Process Insulin Secretion Involved In Cellular Response To Glucose Stimulus Establishment Or Maintenance Of Cell Polarity Endosome Localization Cardiolipin Acyl-chain Remodeling Sulfur Oxidation Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Golgi To Vacuole Transport Vesicle Organization Autophagic Vacuole Fusion Protein Localization To Endosome Regulation Of Cardiac Muscle Cell Membrane Potential Plasma Membrane Organization Synaptic Vesicle Priming	Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis
Tagcloud ?		accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repressed repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Difference) ?		accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Intersection) ?		repressed