EHD1 and MICAL1

Number of citations of the paper that reports this interaction (PubMedID 20106972)
35

Data Source:
BioGRID (two hybrid, two hybrid)

		EHD1	MICAL1
Description		EH domain containing 1	microtubule associated monooxygenase, calponin and LIM domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Lipid Droplet Plasma Membrane Cilium Endosome Membrane Membrane Ciliary Pocket Membrane Endocytic Vesicle Platelet Dense Tubular Network Membrane Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Presynaptic Active Zone Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Glutamatergic Synapse	Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Intermediate Filament Actin Filament Plasma Membrane Cilium Endosome Membrane Actin Cytoskeleton Membrane Midbody Ciliary Basal Body Intercellular Bridge Plasma Membrane Bounded Cell Projection Hippocampal Mossy Fiber Expansion
	Molecular Function	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding	Actin Binding Monooxygenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding F-actin Monooxygenase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Cell Projection Organization Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling	Cytoskeleton Organization Signal Transduction Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway
Pathways		Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Depression in smokers ( 30219690) Height ( 28552196)
Interacting Genes		13 interacting genes: AP2A1 EHBP1 EHD3 HSPB1 IGF1R MICAL1 MUL1 OGT PACSIN2 RAB11FIP2 RBSN RFFL SNAP29	16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM
Entrez ID		10938	64780
HPRD ID		09325	06183
Ensembl ID		ENSG00000110047	ENSG00000135596
Uniprot IDs		A0A024R571 B2R5U3 Q9H4M9	Q8TDZ2
PDB IDs		2JQ6 2KFF 2KFG 2KFH 2KSP	1WYL 2CO8 2DK9 5LE0 5LPN 6KU0 8HLO 8Y6K 9EWY
Enriched GO Terms of Interacting Partners?		Intracellular Protein Localization Vesicle-mediated Transport Protein Transport Endosome Establishment Of Protein Localization Recycling Endosome Membrane Plasma Membrane Ciliary Pocket Membrane Protein Kinase Binding Endocytosis Golgi To Lysosome Transport Cilium Endosome Membrane Import Into Cell Post-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport Regulation Of Golgi Organization Golgi To Vacuole Transport Cytosolic Transport Membrane Establishment Of Localization In Cell Negative Regulation Of Protein Kinase C Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ciliary Membrane Cytosol Regulation Of Cellular Component Organization Cellular Response To Glucose Stimulus Golgi Vesicle Transport Small GTPase Binding Intracellular Transport P53 Binding Cellular Response To Carbohydrate Stimulus Sulfur Oxidation Hippocampal Mossy Fiber Expansion Cell Projection Early Endosome Negative Regulation Of Intracellular Signal Transduction Protein Kinase C Inhibitor Activity Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Intracellular Glucose Homeostasis Insulin Receptor Activity Protein O-acetylglucosaminyltransferase Activity TRAM-dependent Toll-like Receptor 4 Signaling Pathway F-actin Monooxygenase Activity Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Retrograde Transport, Endosome To Golgi Positive Regulation Of Cold-induced Thermogenesis	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion SH2 Domain Binding Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Organelle Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Cell Migration Scaffold Protein Binding Positive Regulation Of Cell Motility Negative Regulation Of Anoikis ERBB Signaling Pathway Positive Regulation Of Locomotion Nucleotide Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Establishment Of Cell Polarity Regulation Of Cell Projection Organization Protein Domain Specific Binding Regulation Of Anoikis Integrin-mediated Signaling Pathway Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cellular Response To Fluid Shear Stress Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Epithelial Cell Development Regulation Of Cytoskeleton Organization Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Metabolic Process Developmental Process Response To Fluid Shear Stress Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Mononuclear Cell Migration
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