EHD1 and PLA2G4A

Number of citations of the paper that reports this interaction (PMID 22456504)
7

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		EHD1	PLA2G4A
Gene Name		EH-domain containing 1	phospholipase A2, group IVA (cytosolic, calcium-dependent)
Image
Gene Ontology Annotations	Cellular Component	Lipid Particle Plasma Membrane Endosome Membrane Membrane Platelet Dense Tubular Network Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Vesicular Exosome	Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding ATP Binding GTP Binding Rab GTPase Binding	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Cholesterol Storage Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Blood Coagulation Phospholipid Catabolic Process Arachidonic Acid Metabolic Process Platelet Activation Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Small Molecule Metabolic Process Icosanoid Biosynthetic Process Glycerophospholipid Biosynthetic Process Arachidonic Acid Secretion Cellular Response To Antibiotic
Pathways		Factors involved in megakaryocyte development and platelet production	phospho-PLA2 pathway Ca-dependent events Signaling by GPCR Acyl chain remodeling of CL ADP signalling through P2Y purinoceptor 1 Hydrolysis of LPC Acyl chain remodelling of PE Metabolism of lipids and lipoproteins Signal amplification Arachidonic acid metabolism Phospholipid metabolism Acyl chain remodelling of PC Synthesis of PA PLC beta mediated events Opioid Signalling Glycerophospholipid biosynthesis G-protein mediated events Acyl chain remodelling of PS Acyl chain remodelling of PG Platelet homeostasis Acyl chain remodelling of PI Platelet sensitization by LDL Platelet activation, signaling and aggregation
Drugs			Fluticasone Propionate Quinacrine Niflumic Acid
Diseases
GWAS			Epilepsy (generalized) ( 22949513) Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		12 interactors: ANKFY1 AP2A1 CLTC EHBP1 EHD3 IGF1R MICAL1 MICALL1 PLA2G4A RAB11FIP2 RBSN SNAP29	18 interactors: C17orf59 CAP1 CASP1 CASP3 CASP4 EHD1 JAK1 KAT5 MAPK14 MAPKAPK5 MKNK1 PLA2G5 RELA RPS6KA5 SHBG UBXN1 VIM XAGE1E
Entrez ID		10938	5321
HPRD ID		09325	08986
Ensembl ID		ENSG00000110047	ENSG00000116711
Uniprot IDs		B2R5U3 Q9H4M9	E7EU42 P47712
PDB IDs		2JQ6 2KFF 2KFG 2KFH 2KSP	1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Negative Regulation Of Hyaluronan Biosynthetic Process Endosomal Transport Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Cellular Localization Membrane Organization Endocytic Recycling Protein Localization Endocytosis Transport Golgi Vesicle Transport Intracellular Transport Vesicle Fusion Receptor-mediated Endocytosis Intracellular Protein Transport Inactivation Of MAPKK Activity Slow Endocytic Recycling Organelle Fusion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Cell Polarity Endosomal Vesicle Fusion Golgi To Lysosome Transport Positive Regulation Of Pinocytosis Membrane Fusion Regulation Of Body Fluid Levels Cellular Protein Localization Platelet Activating Factor Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Secretion Protein Targeting To Membrane Platelet Activating Factor Metabolic Process Insulin Secretion Involved In Cellular Response To Glucose Stimulus Establishment Or Maintenance Of Cell Polarity Endosome Localization Cardiolipin Acyl-chain Remodeling Sulfur Oxidation Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Golgi To Vacuole Transport Vesicle Organization Autophagic Vacuole Fusion Protein Localization To Endosome Regulation Of Cardiac Muscle Cell Membrane Potential Plasma Membrane Organization Synaptic Vesicle Priming	Cellular Response To Organic Substance Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Apoptotic Process Response To Growth Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Programmed Cell Death Activation Of Innate Immune Response Cell Death Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cytokine Production Stress-induced Premature Senescence Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Response To Abiotic Stimulus Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-serine Phosphorylation Response To Tumor Necrosis Factor Signal Transduction
Tagcloud ?		accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repressed repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repressed repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?