WDR3 and HSPA13

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		WDR3	HSPA13
Name		WD repeat domain 3	heat shock protein family A (Hsp70) member 13
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	RNA Binding SnoRNA Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone
	Biological Process	Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis	Protein Folding Protein Refolding
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Regulation of HSF1-mediated heat shock response
Drugs		None	Copper
GWAS		Age-related hearing impairment ( 34108613 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: CCAR2 HSPA13 NOP58 PDE10A	43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT
Entrez ID		10885	6782
HPRD ID		16066	03061
Ensembl ID		ENSG00000065183	ENSG00000155304
Uniprot IDs		Q5TDG3 Q9UNX4	A0A140VK72 P48723
PDB IDs		7MQ8 7MQ9 7MQA	Not available
GO Terms Enriched among Interactors		Negative Regulation Of CGMP-mediated Signaling 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Cyclic-nucleotide Phosphodiesterase Activity CGMP Catabolic Process SnoRNA Localization Box C/D Methylation Guide SnoRNP Complex Positive Regulation Of DNA Damage Checkpoint DBIRD Complex CAMP Catabolic Process TFIID-class Transcription Factor Complex Binding Pre-snoRNP Complex Sno(s)RNA-containing Ribonucleoprotein Complex Mitochondrial Fragmentation Involved In Apoptotic Process Regulation Of Protein Deacetylation 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP Metabolic Process 3',5'-cyclic-GMP Phosphodiesterase Activity CGMP Binding Cyclic Nucleotide Catabolic Process Regulation Of CGMP-mediated Signaling CAMP Binding Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway SnoRNA Binding Adenyl-nucleotide Exchange Factor Activity Positive Regulation Of Cell Cycle Checkpoint Regulation Of DNA Damage Checkpoint CAMP Metabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Protein Refolding	Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process