WDR3 and NOP58

Number of citations: 38 (PubMedID 30217970)
Data Source: BioGRID (two hybrid)

		WDR3	NOP58
Name		WD repeat domain 3	NOP58 ribonucleoprotein
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytosol Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding SnoRNA Binding	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding SnoRNA Binding ATPase Binding
	Biological Process	Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis SnoRNA Localization
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	SUMOylation of RNA binding proteins rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
GWAS		Age-related hearing impairment ( 34108613 )	No GWAS studies recorded
Novel Interactors		None recorded	2 novel interactors: PPIL3 SF3B1
Interacting Genes		4 interacting genes: CCAR2 HSPA13 NOP58 PDE10A	8 interacting genes: ANXA1 CEBPA CSNK2A1 MAP4 OGT PTEN UBE2I WDR3
Entrez ID		10885	51602
HPRD ID		16066	11036
Ensembl ID		ENSG00000065183	ENSG00000055044
Uniprot IDs		Q5TDG3 Q9UNX4	Q9Y2X3
PDB IDs		7MQ8 7MQ9 7MQA	7MQ8 7MQ9 7MQA
GO Terms Enriched among Interactors		Negative Regulation Of CGMP-mediated Signaling 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Cyclic-nucleotide Phosphodiesterase Activity CGMP Catabolic Process SnoRNA Localization Box C/D Methylation Guide SnoRNP Complex Positive Regulation Of DNA Damage Checkpoint DBIRD Complex CAMP Catabolic Process TFIID-class Transcription Factor Complex Binding Pre-snoRNP Complex Sno(s)RNA-containing Ribonucleoprotein Complex Mitochondrial Fragmentation Involved In Apoptotic Process Regulation Of Protein Deacetylation 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP Metabolic Process 3',5'-cyclic-GMP Phosphodiesterase Activity CGMP Binding Cyclic Nucleotide Catabolic Process Regulation Of CGMP-mediated Signaling CAMP Binding Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway SnoRNA Binding Adenyl-nucleotide Exchange Factor Activity Positive Regulation Of Cell Cycle Checkpoint Regulation Of DNA Damage Checkpoint CAMP Metabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Protein Refolding	Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Macromolecule Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Development RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Membraneless Organelle Assembly Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly SUMO Conjugating Enzyme Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly U11/U12 SnRNP Lipid Binding Positive Regulation Of Protein Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Negative Regulation Of Non-motile Cilium Assembly Microtubule Stabilizing Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Catalytic Step 2 Spliceosome Organelle Organization Protein Localization To Vacuole Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Negative Regulation Of Developmental Process CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translational Initiation Protein Kinase CK2 Complex