TNS1

Name	tensin 1
Structure	No pdb structure
Interactors	16 interactors: AR CAPN2 EGFR ERBB2 ERBB3 ERBB4 FRS3 GAB1 KIT KLF10 MET OSGEP PPP1CC PTK2 RNF10 YWHAZ
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Focal Adhesion Cell Surface Cell-substrate Junction Anchoring Junction
	Molecular Function	RNA Binding Actin Binding Phosphoprotein Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Cell-substrate Junction Assembly Fibroblast Migration
GWAS	Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Asthma and hay fever ( 24388013 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 33909500 30804561 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Coronary artery disease ( 33020668 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 28135244 ) Diverticular disease ( 30177863 ) FEV1 ( 30804560 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels in HIV infection ( 33109212 ) Height ( 20881960 28552196 25429064 25282103 21998595 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Intraocular pressure ( 30054594 29785010 29617998 29235454 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Lung function (FVC) ( 30804560 28166213 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Mitral valve prolapse ( 26301497 ) Myocardial infarction ( 33532862 ) Pulmonary function ( 20010834 ) Pulmonary function (smoking interaction) ( 23284291 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 27841878 30578418 )
Entrez ID	7145
HPRD ID	02512
Ensembl ID	ENSG00000079308
Uniprot IDs	A0A2R8Y4T1 A1L0S7 B2RU35 B7Z6H8 E9PF55 E9PGF5 Q0VG54 Q0VG55 Q59G71 Q86VB0 Q9HBL0
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Developmental Process Basal Plasma Membrane ERBB2 Signaling Pathway Receptor Complex Protein Phosphatase Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Protein Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Neuron Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Kinase Activity Positive Regulation Of Epithelial Cell Proliferation ERBB3:ERBB2 Complex Regulation Of MAPK Cascade Animal Organ Development Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process Transferase Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation