NEK6 and CCDC36

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NEK6	CCDC36
Gene Name		NIMA-related kinase 6	coiled-coil domain containing 36
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol Microtubule Nuclear Speck
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Cytokinesis Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition G2 DNA Damage Checkpoint Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Regulation Of Cellular Senescence
Pathways		Mitotic Prophase Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown Nuclear Pore Complex (NPC) Disassembly Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		42 interactors: AES ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC36 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 FAM208B HSD17B14 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TCF4 TGFBR1 TNK2 TRIM23 TRIM27 TRIP4 XIAP	33 interactors: ABI2 AQP1 C1orf109 CARD9 CDC23 COX5B DGCR6 DYNLL1 DYNLL2 FAM124A FANCL FKBP6 GYS1 HEXIM2 IQUB KANK2 KLC3 LMO2 LONRF1 MRFAP1L1 MVP MYO15B NEK6 NGB POLR1C PRKAB2 RUNX1T1 SDCBP STK25 TRIM42 TTC19 USP2 USP20
Entrez ID		10783	339834
HPRD ID		05348	14172
Ensembl ID		ENSG00000119408	ENSG00000173421
Uniprot IDs		Q9HC98	B4DZP6 Q8IYA8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Biosynthetic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Binding Regulation Of Phosphorylation Negative Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Protein Phosphorylation Regulation Of Growth Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Cellular Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Ubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Signaling Negative Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Endothelial Cell Activation Wnt Signaling Pathway	Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Organelle Organization Organelle Organization Regulation Of Cell Cycle Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Cycle Regulation Of Proteolysis Regulation Of Protein Catabolic Process Ammonium Transmembrane Transport Positive Regulation Of Organelle Organization Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Synaptic Target Recognition Regulation Of Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrion Organization Cellular Response To Hydrogen Peroxide Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Vitamin D Receptor Signaling Pathway Carbon Dioxide Transmembrane Transport Corticotropin Secretion Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Cell Cycle Phase Transition Positive Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ammonium Transport Proteasomal Protein Catabolic Process
Tagcloud ?		23a abolishes attenuated attenuates berberine biogenesis chromatin detecting g2 gadd45alpha hcc hepatocellular immunoblotting mature mediate mediating microrna mir monitored onto p21 precursor prediction reveals suppress suppressive transcript upon validation
Tagcloud (Difference) ?		23a abolishes attenuated attenuates berberine biogenesis chromatin detecting g2 gadd45alpha hcc hepatocellular immunoblotting mature mediate mediating microrna mir monitored onto p21 precursor prediction reveals suppress suppressive transcript upon validation
Tagcloud (Intersection) ?