NEK6 and ZNF587

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NEK6	ZNF587
Description		NIMA related kinase 6	zinc finger protein 587
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite	Nucleus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Generic Transcription Pathway
Drugs
Diseases
GWAS		Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
Interacting Genes		119 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEBPA CEP76 CFP CIRSR COG6 CTBP2 DDIT4L DES DPH2 EFHC2 EML4 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SAXO5 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1	130 interacting genes: ADAMTSL4 AQP6 ASB15 ASB6 AXIN2 BEGAIN C17orf50 CARD10 CARD9 CCDC125 CCDC136 CCDC85B CEP44 CEP70 CHRDL2 CSRNP1 CYSRT1 DEF8 DHX57 EFEMP2 FCHSD2 FHL3 FHL5 FSD2 FST GOLGA2 GOLGA6L9 GOPC GSC2 HMBOX1 HOOK2 HOXA1 HSF2BP IGFBP6 IKBKG IKZF1 IKZF3 INSC ISY1-RAB43 KATNBL1 KCTD7 KPRP KRT31 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-7 KRTAP5-9 LDOC1 LHX3 LIMS1 LMO3 LRP2BP LZTS1 MCCD1 MDFI MEOX2 MID2 MKRN3 MTUS2 MYF5 NBPF19 NDUFB7 NEK6 NKAPL NOTCH2NLA NR1D2 PBX2 PDE4DIP PLSCR1 PNMA2 PPARA PRDM14 PRICKLE4 PRPF31 RORB RUNDC3A SMAD9 SMYD5 SOX13 SPRED1 SPRY2 SPRY3 SSX2IP STX11 TBC1D26 TCF4 TENM4 TFIP11 TMCC2 TNS2 TRAF1 TRIB3 TRIM23 TRIM27 TRIM36 TRIM37 TRIM41 TRIM54 TSC1 TSGA10 TXK VPS52 VWC2 ZBTB43 ZBTB8A ZGPAT ZIM2 ZKSCAN8 ZNF286A ZNF330 ZNF417 ZNF547 ZNF774 ZNF829 ZNF837 ZRANB1
Entrez ID		10783	84914
HPRD ID		05348	15864
Ensembl ID		ENSG00000119408	ENSG00000198466
Uniprot IDs		Q9HC98	Q96SQ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Intermediate Filament Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Binding DNA-binding Transcription Factor Activity Intermediate Filament Organization Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Centrosome DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleus Supramolecular Fiber Organization Negative Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Cytosol Ubiquitin Protein Ligase Activity DNA Binding Sno(s)RNA Catabolic Process Z Disc Intermediate Filament Cytoskeleton SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Cellular Component Organization Cell Differentiation Structural Constituent Of Cytoskeleton	Intermediate Filament Keratin Filament Zinc Ion Binding Protein Binding Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity
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