NEK6 and PRAM1

Number of citations of the paper that reports this interaction (PubMedID 20873783)
0

Data Source:
BioGRID (two hybrid, pull down, enzymatic study)

		NEK6	PRAM1
Description		NIMA related kinase 6	PML-RARA regulated adaptor molecule 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite	Plasma Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	Protein Binding Lipid Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Integrin-mediated Signaling Pathway Regulation Of Neutrophil Degranulation T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Coronary artery disease ( 29212778) Height ( 18391951)
Interacting Genes		119 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEBPA CEP76 CFP CIRSR COG6 CTBP2 DDIT4L DES DPH2 EFHC2 EML4 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SAXO5 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1	26 interacting genes: A2M ABI2 APOE APP BCAR1 CCDC57 CDC37 CEBPA FXR1 FXR2 GOLGA2 KRT40 LCP2 LYN MAST1 MXD1 NEDD9 NEK6 PSEN1 RNF32 SH3RF1 SKAP1 SKAP2 TP53BP2 TRIM27 UBE2E2
Entrez ID		10783	84106
HPRD ID		05348	05926
Ensembl ID		ENSG00000119408	ENSG00000133246
Uniprot IDs		Q9HC98	Q96QH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Intermediate Filament Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Binding DNA-binding Transcription Factor Activity Intermediate Filament Organization Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Centrosome DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleus Supramolecular Fiber Organization Negative Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Cytosol Ubiquitin Protein Ligase Activity DNA Binding Sno(s)RNA Catabolic Process Z Disc Intermediate Filament Cytoskeleton SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Cellular Component Organization Cell Differentiation Structural Constituent Of Cytoskeleton	Positive Regulation Of Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation SH3 Domain Binding Regulation Of Dendritic Spine Maintenance Regulation Of Immune System Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Amyloid Fibril Formation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Regulation Of Immune Response Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Proteolysis Regulation Of Synaptic Plasticity Astrocyte Activation Involved In Immune Response Positive Regulation Of Protein Catabolic Process Intermediate-density Lipoprotein Particle Positive Regulation Of Dendritic Spine Maintenance Growth Factor Receptor Binding T Cell Receptor Signaling Pathway Memory Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Long-term Synaptic Potentiation Cytoplasm Learning Or Memory Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Amyloid-beta Signaling Receptor Activator Activity Regulation Of Amyloid Precursor Protein Catabolic Process Cytoskeleton Organization Regulation Of Synapse Organization Cytosol Supramolecular Fiber Organization Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Immune System Process Cognition Positive Regulation Of Phosphate Metabolic Process Response To Amyloid-beta Neuron Projection Positive Regulation Of Metabolic Process Regulation Of Defense Response Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Neuron Projection Maintenance
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