NEK6 and NUDT16L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NEK6	NUDT16L1
Description		NIMA related kinase 6	nudix hydrolase 16 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite	Nucleus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	RNA Binding Protein Binding SnoRNA Binding Protein Homodimerization Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	MRNA Catabolic Process Sno(s)RNA Catabolic Process Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)
Interacting Genes		119 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEBPA CEP76 CFP CIRSR COG6 CTBP2 DDIT4L DES DPH2 EFHC2 EML4 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SAXO5 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1	52 interacting genes: APP CABP2 CEBPA ERBB2 FBXO7 HNRNPF HNRNPH1 IKZF3 INCA1 KRT31 LRRK1 METTL17 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR18B MIR200C MIR21 MIR25 MIR31 MIR34A MIR34B MIR363 MIR451A MIR7-3 MIR9-1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4L NEK6 NTAQ1 PNMA1 RECK SMARCD1 TRAF2 TRAF4 TRIM68 ZRANB1
Entrez ID		10783	84309
HPRD ID		05348	15309
Ensembl ID		ENSG00000119408	ENSG00000168101
Uniprot IDs		Q9HC98	B2RD96 K7ENA3 Q9BRJ7 W4VSQ8
PDB IDs			3KVH 5ZCJ 6CO1 6D0L 8U3S
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Intermediate Filament Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Binding DNA-binding Transcription Factor Activity Intermediate Filament Organization Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Centrosome DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleus Supramolecular Fiber Organization Negative Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Cytosol Ubiquitin Protein Ligase Activity DNA Binding Sno(s)RNA Catabolic Process Z Disc Intermediate Filament Cytoskeleton SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Cellular Component Organization Cell Differentiation Structural Constituent Of Cytoskeleton	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Biosynthetic Process RNA Destabilization Negative Regulation Of Metabolic Process Positive Regulation Of MRNA Catabolic Process Extracellular Vesicle Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Angiogenesis Regulation Of Vasculature Development Extracellular Space Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus
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