NEK6 and TNK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NEK6	TNK2
Description		NIMA related kinase 6	tyrosine kinase non receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Grb2-EGFR Complex Cytoophidium
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Endocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Signaling by LTK
Drugs			ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases
GWAS		Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)	Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)
Interacting Genes		119 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEBPA CEP76 CFP CIRSR COG6 CTBP2 DDIT4L DES DPH2 EFHC2 EML4 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SAXO5 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1	52 interacting genes: AKT1 AQP1 AR ARSL ATP5F1A BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R1 PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 UBC VTI1B WAS WWOX WWP2 YES1
Entrez ID		10783	10188
HPRD ID		05348	06104
Ensembl ID		ENSG00000119408	ENSG00000061938
Uniprot IDs		Q9HC98	A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 A0A5F9ZHP4 A0A5F9ZI29 B3KXJ4 C9J1X3 Q07912
PDB IDs			1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB 6VQM 7KP6 8FE9 8FZ3 8HMT 8Q5P 8THA
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Intermediate Filament Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Binding DNA-binding Transcription Factor Activity Intermediate Filament Organization Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Centrosome DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regulation Of Metabolic Process Nucleus Supramolecular Fiber Organization Negative Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Cytosol Ubiquitin Protein Ligase Activity DNA Binding Sno(s)RNA Catabolic Process Z Disc Intermediate Filament Cytoskeleton SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Cellular Component Organization Cell Differentiation Structural Constituent Of Cytoskeleton	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell-cell Junction Ephrin Receptor Binding Signal Transduction Cell Migration Cell Motility Regulation Of Cell Projection Organization Intracellular Signal Transduction Regulation Of Signal Transduction Leukocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization T Cell Costimulation Actin Filament Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Cell Activation Regulation Of Apoptotic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Lymphocyte Activation Negative Regulation Of Apoptotic Process Regulation Of Actin Filament Organization Positive Regulation Of Locomotion Regulation Of Protein Localization To Plasma Membrane Plasma Membrane Protein Autophosphorylation Cell Differentiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Biological Quality Protein Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Locomotion
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