ARHGEF11 and LPAR2

Number of citations of the paper that reports this interaction (PubMedID 15755723)
0

Data Source:
HPRD (in vitro, in vivo)

		ARHGEF11	LPAR2
Description		Rho guanine nucleotide exchange factor 11	lysophosphatidic acid receptor 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Plasma Membrane Cell Surface Membrane Endocytic Vesicle Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	G Protein-coupled Receptor Activity Protein Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Regulation Of Small GTPase Mediated Signal Transduction	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of MAPK Cascade
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Schizophrenia ( 23974872) Sphingolipid levels ( 22359512)
Interacting Genes		16 interacting genes: ABCA1 CDC42 GNA12 GNA13 KLHL20 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6	7 interacting genes: ARHGEF11 ARHGEF12 ATXN1 GIPC1 NHERF1 NHERF2 TRIP6
Entrez ID		9826	9170
HPRD ID		09302	05487
Ensembl ID		ENSG00000132694	ENSG00000064547
Uniprot IDs		A0AAQ5BIK5 O15085	Q9HBW0
PDB IDs		1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT	4P0C
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Shape Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Semaphorin-plexin Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Morphogenesis Cell Junction Assembly Semaphorin Receptor Activity Semaphorin Receptor Complex Positive Regulation Of Cellular Component Organization Regulation Of Biological Quality G Protein Activity Glutamatergic Synapse Neuronal Cell Body Positive Regulation Of Cell Projection Organization D5 Dopamine Receptor Binding Positive Regulation Of Axonogenesis Regulation Of Rho Protein Signal Transduction Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Regulation Of Developmental Process Regulation Of Cell Motility Positive Regulation Of Rho Protein Signal Transduction Synapse Assembly Regulation Of Locomotion Cell Junction Organization Lysophosphatidic Acid Receptor Activity Regulation Of Cytoskeleton Organization Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Axonogenesis Membrane Invagination Cell Migration Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Ossification Involved In Bone Maturation Rho Protein Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Endocytic Vesicle	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Regulation Of Signal Transduction Phosphatase Binding Acidic Amino Acid Transport G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Signaling Receptor Binding Renal Phosphate Ion Absorption Rho Protein Signal Transduction G Protein-coupled Receptor Binding Establishment Of Cell Polarity Beta-catenin Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Amino Acid Transport Signal Transduction POZ Domain Binding Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Identical Protein Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Molecular Adaptor Activity Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Intracellular Phosphate Ion Homeostasis Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Establishment Or Maintenance Of Cell Polarity Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Melanin Biosynthetic Process Rho-activating G Protein-coupled Receptor Signaling Pathway Nuclear Inclusion Body Interleukin-1 Receptor Binding Regulation Of Intracellular Signal Transduction Endomembrane System Extracellular Exosome Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport
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