RAP2A and ENSA

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		RAP2A	ENSA
Gene Name		RAP2A, member of RAS oncogene family	endosulfine alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Phosphatase Inhibitor Activity Receptor Binding Ion Channel Inhibitor Activity Protein Phosphatase Type 2A Regulator Activity Phosphatase Inhibitor Activity Potassium Channel Inhibitor Activity Protein Phosphatase 2A Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transport Mitotic Nuclear Division Response To Nutrient Response To Glucose Negative Regulation Of Catalytic Activity Regulation Of Catalytic Activity Regulation Of Insulin Secretion Cell Division
Pathways			MASTL Facilitates Mitotic Progression Mitotic Prophase Cell Cycle, Mitotic M Phase
Drugs		Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		32 interactors: ACVR1 ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 MLLT4 NEDD4 PLG RAF1 RALA RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	9 interactors: ABCC8 ACD ARIH2 ENO2 KCTD15 POT1 PSEN1 RAP2A SNCA
Entrez ID		5911	2029
HPRD ID		01547	11927
Ensembl ID			ENSG00000143420
Uniprot IDs		P10114	A6NMQ3 O43768
PDB IDs		1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Response To Stimulus Regulation Of Signaling Regulation Of Catalytic Activity Cell Communication Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Rap GTPase Activity Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Rap Protein Signal Transduction Signal Transduction By Phosphorylation Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ras Protein Signal Transduction Regulation Of Dendrite Morphogenesis Response To Wounding Regulation Of Cell Projection Organization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Platelet Activation Regulation Of Ras GTPase Activity Cellular Response To Growth Factor Stimulus Response To Organic Substance Regulation Of Cellular Process Response To Growth Factor Regulation Of Dendrite Development Cardiovascular System Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cellular Localization Cell Differentiation Blood Vessel Development Response To Stress Vasculature Development Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Activation Of MAPKK Activity	Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Positive Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Receptor Recycling Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Transferase Activity Regulation Of Receptor Recycling Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of DNA Replication Telomere Maintenance Ammonium Transport Cellular Component Assembly Regulation Of Cellular Component Organization Negative Regulation Of Thrombin Receptor Signaling Pathway Cajal-Retzius Cell Differentiation Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Beta-amyloid Formation Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Synaptic Vesicle Transport Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Segmentation Negative Regulation Of Biosynthetic Process Regulation Of DNA Replication Negative Regulation Of Dopamine Metabolic Process Telomere Formation Via Telomerase Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Cellular Respiration Synaptic Transmission Regulation Of Neurotransmitter Levels Positive Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Synaptic Vesicle Targeting
Tagcloud ?		cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Difference) ?		cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Intersection) ?