RAP2A and RRP9

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		RAP2A	RRP9
Description		RAP2A, member of RAS oncogene family	ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
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GO Annotations	Cellular Component	Lysosome Endosome Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Midbody Cytoplasmic Vesicle Membrane Lamellipodium Membrane Endolysosome Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane Synaptic Membrane Bounding Membrane Of Organelle Schaffer Collateral - CA1 Synapse	Nucleus Nucleoplasm Nucleolus Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	RNA Binding Protein Binding SnoRNA Binding U3 SnoRNA Binding
	Biological Process	Signal Transduction Intracellular Protein Localization Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Rap Protein Signal Transduction Establishment Of Protein Localization Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Microvillus Assembly	RRNA Processing Ribosomal Small Subunit Biogenesis
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAB40B RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	4 interacting genes: CSNK2A1 RAP2A SIRT7 SMURF1
Entrez ID		5911	9136
HPRD ID		01547	08827
Ensembl ID		ENSG00000125249	ENSG00000114767
Uniprot IDs		P10114	O43818
PDB IDs		1KAO 2RAP 3RAP	4J0W 4JXM 7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling GTPase Regulator Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Microvillus Assembly Protein Kinase Activity Establishment Of Endothelial Barrier Activin Receptor Complex Activin Receptor Activity, Type I NMDA Glutamate Receptor Activity Glutamate Binding Endothelial Cell Development Guanyl-nucleotide Exchange Factor Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition SMAD Binding NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Kinase Activity Potassium Channel Inhibitor Activity Excitatory Chemical Synaptic Transmission Regulation Of Microvillus Assembly Activin Binding Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Plasma Membrane Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Nucleotide Binding Regulation Of Insulin Secretion Response To Growth Factor Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway I-SMAD Binding Positive Regulation Of Cellular Component Biogenesis	Protein Targeting To Vacuole Involved In Autophagy Regulation Of Cellular Response To Stress Protein Localization To Vacuole Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Nucleolus Organizer Region Protein-glutaryllysine Deglutarylase Activity Engulfment Of Target By Autophagosome Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Intracellular Signal Transduction Positive Regulation Of Aggrephagy Positive Regulation Of Microvillus Assembly Protein Targeting Sulfatide Binding Activin Receptor Binding Regulation Of DNA Repair Regulation Of Anatomical Structure Morphogenesis Endolysosome ATF6-mediated Unfolded Protein Response NAD-dependent Protein Lysine Deacetylase Activity Substrate Localization To Autophagosome Positive Regulation Of Growth Positive Regulation Of RRNA Processing R-loop Processing Rap Protein Signal Transduction Regulation Of Microvillus Assembly Sarcoplasmic Reticulum Lumen Wnt Signaling Pathway Double-strand Break Repair Via Classical Nonhomologous End Joining Aggrephagy Regulation Of Cellular Component Organization Signal Transduction Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Establishment Of Protein Localization To Organelle Positive Regulation Of Systemic Arterial Blood Pressure Low-density Lipoprotein Particle Receptor Activity Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of RRNA Processing Protein Deacetylation Protein Methyltransferase Activity
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