RAP2A and RAB40B

Number of citations of the paper that reports this interaction (PubMedID 35293963)
87

Data Source:
BioGRID (pull down, imaging technique)

		RAP2A	RAB40B
Description		RAP2A, member of RAS oncogene family	RAB40B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Midbody Cytoplasmic Vesicle Membrane Lamellipodium Membrane Endolysosome Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane Synaptic Membrane Bounding Membrane Of Organelle Schaffer Collateral - CA1 Synapse	Ruffle Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Lamellipodium Lamellipodium Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Signal Transduction Intracellular Protein Localization Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Rap Protein Signal Transduction Establishment Of Protein Localization Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Microvillus Assembly	Exocytosis Protein Ubiquitination Positive Regulation Of Cell Migration Negative Regulation Of Actin Filament Bundle Assembly Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Lamellipodium Organization Cellular Detoxification
Pathways			RAB geranylgeranylation
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Colorectal cancer or advanced adenoma ( 30510241)
Interacting Genes		32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAB40B RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	10 interacting genes: ANKRD27 APP CRYAA EFEMP2 FHIT FHL3 RAP2A RAP2B RAP2C WFDC1
Entrez ID		5911	10966
HPRD ID		01547	11472
Ensembl ID		ENSG00000125249	ENSG00000141542
Uniprot IDs		P10114	Q12829
PDB IDs		1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling GTPase Regulator Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Microvillus Assembly Protein Kinase Activity Establishment Of Endothelial Barrier Activin Receptor Complex Activin Receptor Activity, Type I NMDA Glutamate Receptor Activity Glutamate Binding Endothelial Cell Development Guanyl-nucleotide Exchange Factor Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition SMAD Binding NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Kinase Activity Potassium Channel Inhibitor Activity Excitatory Chemical Synaptic Transmission Regulation Of Microvillus Assembly Activin Binding Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Plasma Membrane Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Nucleotide Binding Regulation Of Insulin Secretion Response To Growth Factor Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway I-SMAD Binding Positive Regulation Of Cellular Component Biogenesis	Rap Protein Signal Transduction Bounding Membrane Of Organelle Recycling Endosome Cytoplasmic Vesicle Membrane GDP Binding Endomembrane System G Protein Activity Recycling Endosome Membrane Endosome Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Tyrosine Kinase Activity Cell-cell Contact Zone Establishment Of Endothelial Barrier Endothelial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylylsulfatase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Diadenosine Triphosphate Catabolic Process Regulation Of Dendrite Morphogenesis Small GTPase-mediated Signal Transduction Tertiary Granule Membrane Positive Regulation Of Smooth Muscle Cell-matrix Adhesion GTPase Activity Negative Regulation Of Cell Migration Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Development Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Import GTP Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Negative Regulation Of SNARE Complex Assembly PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
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