TRIM16 and ACD

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TRIM16	ACD
Description		tripartite motif containing 16	ACD shelterin complex subunit and telomerase recruitment factor
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane PML Body	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Interleukin-1 Binding NACHT Domain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Response To Retinoic Acid Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Response To Growth Hormone	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Telomere
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS			Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		8 interacting genes: ACD APP CFTR FNDC3B POT1 SETDB1 TERF1 TINF2	64 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		10626	65057
HPRD ID		15552	12417
Ensembl ID		ENSG00000221926	ENSG00000102977
Uniprot IDs		B3KP96 O95361	A0A8Q3WM11 Q96AP0
PDB IDs		7QS3	2I46 5H65 5I2X 5I2Y 5UN7 5XYF 7QXA 7QXB 7QXS 7S1T 7TRE 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome Telomeric D-loop Disassembly DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Component Organization DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium	Cytoplasm Cytosol Cadherin Binding Carbohydrate Catabolic Process Nuclear Telomere Cap Complex Protein Folding Chaperone Complex Substantia Nigra Development ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Glycolytic Process Telomere Maintenance Cellular Response To Heat ADP Metabolic Process Nicotinamide Nucleotide Metabolic Process Nucleoside Diphosphate Catabolic Process Monosaccharide Metabolic Process Ribonucleoside Diphosphate Catabolic Process Unfolded Protein Binding Telomeric D-loop Binding Telomere Assembly Organelle Organization Neural Nucleus Development Pyruvate Metabolic Process Glucose Metabolic Process Telomere Organization Protein Folding Cortical Cytoskeleton Glucose Catabolic Process Telomeric DNA Binding Protein Binding Shelterin Complex Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoskeleton Microtubule Cytoskeleton Organization Nucleoside Diphosphate Metabolic Process Protein Stabilization Chaperone-mediated Autophagy Microtubule Response To Heat Purine Nucleotide Catabolic Process Nitric-oxide Synthase Regulator Activity TPR Domain Binding Hexose Metabolic Process Microtubule Cytoskeleton Intercellular Bridge Telomeric D-loop Disassembly Hsp90 Protein Binding
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