CENPB and PARP1

Number of citations of the paper that reports this interaction (PMID 12011073)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CENPB	PARP1
Gene Name		centromere protein B, 80kDa	poly (ADP-ribose) polymerase 1
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Chromosome	Nucleus Nuclear Envelope Nucleoplasm Transcription Factor Complex Nucleolus Membrane
	Molecular Function	Chromatin Binding Satellite DNA Binding Centromeric DNA Binding Sequence-specific DNA Binding	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding NAD Binding R-SMAD Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance DNA Repair Base-excision Repair Double-strand Break Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein ADP-ribosylation Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation Cellular Response To Insulin Stimulus Regulation Of Growth Rate DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Protein Poly-ADP-ribosylation Cellular Response To Superoxide Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs			Carba-Nicotinamide-Adenine-Dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3\'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Diseases
GWAS			Melanoma ( 21983785)
Protein-Protein Interactions		17 interactors: ANXA7 APP CDKN1A CSNK2B FBXO25 GADD45A GFI1B GSK3B HAND2 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SMN1 TAC1 TK1	84 interactors: APLF APTX ATM BCL2 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTSB CTSG E2F1 ERCC6 ERG FOXO1 GTF2F1 GZMB GZMM H2AFY HDAC1 HDAC3 HIST1H1A HIST1H1C HIST1H2BA HIST1H4A HIST1H4C HIST2H2AA3 HMGA1 HOXB7 HSPA2 KAT2B LIG3 LZTR1 MED14 MED6 MYBL2 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POLB POU2F1 PRKDC RARA RBM14 RELA RNF146 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO1 SUMO2 SUPT16H SWAP70 TCF4 TP53 TRIM29 UBE2I UHRF1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423
Entrez ID		1059	142
HPRD ID		00314	01435
Ensembl ID		ENSG00000125817	ENSG00000143799
Uniprot IDs		P07199	P09874
PDB IDs		1BW6 1HLV 1UFI	1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Negative Regulation Of Phosphorylation Regulation Of Signaling Anatomical Structure Development Cellular Metabolic Process Response To External Stimulus Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Phosphorylation Response To Organic Substance System Development Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of DNA Binding Response To Hormone Apoptotic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Developmental Process Behavior Programmed Cell Death Cell Death Death Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Binding Tube Development Positive Regulation Of Protein Phosphorylation Suckling Behavior Regulation Of Protein Kinase Activity Cellular Protein Modification Process Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Protein Metabolic Process Axon Guidance Protein ADP-ribosylation Regulation Of Kinase Activity Response To Glucocorticoid Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Response To Corticosteroid Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Import Into Nucleus Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Response To Inorganic Substance	Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process DNA Repair Cellular Response To Stress Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Telomere Maintenance Negative Regulation Of Transcription, DNA-templated Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Gene Expression Apoptotic Signaling Pathway Base-excision Repair Regulation Of Apoptotic Process Biosynthetic Process Cellular Response To Stimulus Organelle Organization Response To Stimulus
Tagcloud ?		agreement altman asian bland cenpa cohen fibrillarin iif immunoassay interstitial kappa ku lia limits nc ncs nor90 oa outside plots pmscl100 ro52 ro60 rp155 sle ssc stored telangiectasia utility	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		agreement altman asian bland cenpa cohen fibrillarin iif immunoassay interstitial kappa ku lia limits nc ncs nor90 oa outside plots pmscl100 ro52 ro60 rp155 sle ssc stored telangiectasia utility	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?