CENPB and LAIR1

Data Source: HiPPIP (Novel)

		CENPB	LAIR1
Name		centromere protein B	leukocyte associated immunoglobulin like receptor 1
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nuclear Body	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Satellite DNA Binding Protein Binding Centromeric DNA Binding Sequence-specific DNA Binding	Protein Binding
	Biological Process	None	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway
Pathways		None	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: LAIR1	8 novel interactors: CENPB CFL2 CNOT3 KIR3DS1 LAIR2 MYH3 PRKCG PTPRH
Interacting Genes		20 interacting genes: ADRB2 ANXA7 APP CDKN1A CENPW FBXO25 GADD45A GFI1B GSK3B HAND2 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SH2D3A SMN1 TAC1 TADA3 TK1	5 interacting genes: APP COL1A1 CSK PTPN11 PTPN6
Entrez ID		1059	3903
HPRD ID		00314	04292
Ensembl ID		ENSG00000125817	ENSG00000167613
Uniprot IDs		P07199	A0A0G2JMI0 A0A0G2JNK8 A0A140T8W3 A8MZ84 D3YTC8 Q6GTX8
PDB IDs		1BW6 1HLV 1UFI 6KDR	3KGR 3RP1 7F9L 7F9M 7F9N
GO Terms Enriched among Interactors		Cellular Response To Amyloid-beta Response To Amyloid-beta NAD+-protein-serine ADP-ribosyltransferase Activity Neuronal Dense Core Vesicle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Nucleus Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Chromatin Organization Regulation Of Developmental Process Positive Regulation Of Programmed Cell Death Regulation Of System Process Regulation Of Protein Localization To Nucleus Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Auto-ADP-ribosylation Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Neuron Apoptotic Process Antifungal Humoral Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cardiac Muscle Hypertrophy NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of MAPK Cascade Negative Regulation Of Macromolecule Biosynthetic Process NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Regulation Of Membrane Potential Response To Yeast Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Cycle Regulation Of Muscle System Process Protein Poly-ADP-ribosylation Regulation Of Neuron Apoptotic Process Regulation Of Transcription By RNA Polymerase II Response To Lipid NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Systemic Arterial Blood Pressure	Face Morphogenesis T Cell Costimulation Negative Regulation Of Neutrophil Activation Myeloid Cell Development Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Myeloid Leukocyte Activation Negative Regulation Of T Cell Activation Peptidyl-tyrosine Dephosphorylation Phosphoprotein Phosphatase Activity Platelet Formation Dephosphorylation Megakaryocyte Development Positive Regulation Of Cell Activation Regulation Of Interleukin-6 Production Immune Response-regulating Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Activation Involved In Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Lymphocyte Activation Hemopoiesis Response To Mechanical Stimulus Sarcomere Organization Cell-cell Junction Protein Tyrosine Kinase Binding Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Vitamin E