CENPB and HAND2

Number of citations of the paper that reports this interaction (PubMedID 11812799)
0

Data Source:
HPRD (two hybrid)

		CENPB	HAND2
Description		centromere protein B	heart and neural crest derivatives expressed 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nuclear Body	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Satellite DNA Binding Protein Binding Centromeric DNA Binding Sequence-specific DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Outflow Tract Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Differentiation Regulation Of Tissue Remodeling Norepinephrine Biosynthetic Process Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Thymus Development Embryonic Skeletal System Development Peripheral Nervous System Neuron Development Roof Of Mouth Development Mesenchyme Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Determination Of Heart Left/right Asymmetry Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Positive Regulation Of P38MAPK Cascade Primary Palate Development Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway
Pathways			Transcriptional regulation by RUNX2 Cardiogenesis
Drugs
Diseases
GWAS			Atrial fibrillation ( 28416822 29892015 30061737 33990960) Chin dimples ( 27182965) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) PR interval ( 32439900)
Interacting Genes		20 interacting genes: ADRB2 ANXA7 APP CDKN1A CENPW FBXO25 GADD45A GFI1B GSK3B HAND2 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SH2D3A SMN1 TAC1 TADA3 TK1	19 interacting genes: CENPB COPS5 DNMT3L EP300 FAM90A1 GATA4 HAND1 HEY2 HEYL KANK2 NPM1 PHOX2A PPP2R5D PRKACA PRKCA RIPPLY1 SPANXN3 TCF3 USP20
Entrez ID		1059	9464
HPRD ID		00314	03872
Ensembl ID		ENSG00000125817	ENSG00000164107
Uniprot IDs		P07199	P61296
PDB IDs		1BW6 1HLV 1UFI 6KDR
Enriched GO Terms of Interacting Partners?		Cellular Response To Amyloid-beta Response To Amyloid-beta NAD+-protein-serine ADP-ribosyltransferase Activity Neuronal Dense Core Vesicle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Nucleus Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Chromatin Organization Regulation Of Developmental Process Positive Regulation Of Programmed Cell Death Regulation Of System Process Regulation Of Protein Localization To Nucleus Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Auto-ADP-ribosylation Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Neuron Apoptotic Process Antifungal Humoral Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cardiac Muscle Hypertrophy NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of MAPK Cascade Negative Regulation Of Macromolecule Biosynthetic Process NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Regulation Of Membrane Potential Response To Yeast Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Cycle Regulation Of Muscle System Process Protein Poly-ADP-ribosylation Regulation Of Neuron Apoptotic Process Regulation Of Transcription By RNA Polymerase II Response To Lipid NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Systemic Arterial Blood Pressure	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Cardiac Septum Morphogenesis Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cardiac Ventricle Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription By RNA Polymerase II Atrioventricular Valve Formation Mesenchymal Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Anterior/posterior Pattern Specification Heart Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Fate Commitment DNA-binding Transcription Factor Binding Protein Dimerization Activity Nucleoplasm DNA-binding Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Cardiac Right Ventricle Morphogenesis Heart Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Nucleus System Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Tissue Development
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