SEMA4B and GIPC1

Number of citations of the paper that reports this interaction (PubMedID 15978582)
0

Data Source:
HPRD (in vivo, in vitro)

		SEMA4B	GIPC1
Description		semaphorin 4B	GIPC PDZ domain containing family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding
	Biological Process	Neural Crest Cell Migration Nervous System Development Axon Guidance Cell Differentiation Positive Regulation Of Cell Migration Negative Chemotaxis Semaphorin-plexin Signaling Pathway	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways			FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling
Drugs
Diseases
GWAS		Acne (severe) ( 30542056) Frontal fibrosing alopecia ( 30850646) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Pulse pressure ( 27841878) Serum alkaline phosphatase levels ( 33547301)	Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)
Interacting Genes		4 interacting genes: CPEB2 DLG4 GIPC1 PLXNB1	37 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408
Entrez ID		10509	10755
HPRD ID		10217	05462
Ensembl ID		ENSG00000185033	ENSG00000123159
Uniprot IDs		Q9NPR2	A8K2I7 O14908
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebellar Mossy Fiber Synaptic Vesicle Juxtaparanode Region Of Axon Synaptic Vesicle Maturation P2Y1 Nucleotide Receptor Binding Regulation Of Synaptic Plasticity Locomotory Exploration Behavior Cell Projection Morphogenesis Positive Regulation Of Signal Transduction Neuron Spine Cellular Response To Potassium Ion Positive Regulation Of Neuron Projection Arborization AMPA Glutamate Receptor Clustering Regulation Of Neuron Projection Arborization Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Regulation Of Grooming Behavior NMDA Selective Glutamate Receptor Signaling Pathway Dendritic Spine Neuron Projection Morphogenesis Acetylcholine Receptor Binding Neuron Projection Glutamatergic Synapse Neurotransmitter-gated Ion Channel Clustering Trans-synaptic Signaling Positive Regulation Of Cell Projection Organization Synaptic Signaling Chemical Synaptic Transmission Regulation Of Cell Morphogenesis Neuroligin Family Protein Binding Postsynaptic Membrane Semaphorin Receptor Activity GTPase Activating Protein Binding Negative Regulation Of Osteoblast Proliferation Ossification Involved In Bone Maturation Semaphorin Receptor Complex Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion GTPase Inhibitor Activity Negative Regulation Of Cytoplasmic Translation Negative Regulation Of Translational Elongation Ribosomal Large Subunit Binding Regulation Of Translational Elongation Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Receptor Internalization MRNA Regulatory Element Binding Translation Repressor Activity Response To Potassium Ion	Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility
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