CAP1 and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		CAP1	MYOC
Gene Name		CAP, adenylate cyclase-associated protein 1 (yeast)	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cortical Actin Cytoskeleton Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Actin Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Ameboidal-type Cell Migration Platelet Degranulation Receptor-mediated Endocytosis Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity Axon Guidance Blood Coagulation Actin Cytoskeleton Organization Platelet Activation	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Role of Abl in Robo-Slit signaling Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACTB ACTG1 BARD1 CAP2 LIG4 MYOC PLA2G4A SERPINB8 UCHL5	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		10487	4653
HPRD ID		09869	03387
Ensembl ID		ENSG00000131236	ENSG00000034971
Uniprot IDs		D3DPU2 Q01518	Q99972
PDB IDs		1K8F
Enriched GO Terms of Interacting Partners?		Tissue Homeostasis Platelet Activation Nervous System Development Cell Activation Multicellular Organismal Homeostasis Platelet Aggregation Generation Of Neurons Neuron Projection Development Neurogenesis Homotypic Cell-cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Retina Homeostasis Cellular Response To Stimulus Cell Development Neuron Development Axon Guidance ERBB2-ERBB3 Signaling Pathway DNA Ligation Involved In DNA Recombination Skeletal Muscle Hypertrophy Blood Coagulation Hemostasis Midbrain Development Adherens Junction Organization Neuron Differentiation Response To Stress Cell Projection Organization Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway ERBB2 Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Single Organismal Cell-cell Adhesion Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation DNA Repair Wound Healing Chemotaxis Response To Stimulus Neuron Projection Morphogenesis Platelet Activating Factor Biosynthetic Process System Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activating Factor Metabolic Process Response To Wounding Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		alarco albicans balan brefeldin bzip caglr1 cai4 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants yap1	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		alarco albicans balan brefeldin bzip caglr1 cai4 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants yap1	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?