CAP1 and MYOC

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		CAP1	MYOC
Description		cyclase associated actin cytoskeleton regulatory protein 1	myocilin
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Focal Adhesion Membrane Cortical Actin Cytoskeleton Azurophil Granule Lumen Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Adenylate Cyclase Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Ameboidal-type Cell Migration Receptor-mediated Endocytosis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Actin Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Platelet degranulation Role of ABL in ROBO-SLIT signaling Neutrophil degranulation
Drugs
Diseases			Primary open angle glaucoma
GWAS		Refractive error ( 32231278)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)
Interacting Genes		13 interacting genes: ACTB ACTG1 BARD1 CAP2 CEBPA CFTR FNDC3B LIG4 MYOC PLA2G4A SERPINB8 SNCA UCHL5	41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		10487	4653
HPRD ID		09869	03387
Ensembl ID		ENSG00000131236	ENSG00000034971
Uniprot IDs		D3DPU2 Q01518	A0A0S2Z421 Q99972
PDB IDs		1K8F	4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR
Enriched GO Terms of Interacting Partners?		Regulation Of Norepinephrine Uptake Transporter Regulator Activity Regulation Of Synaptic Vesicle Recycling Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Macrophage Activation Multicellular Organismal-level Homeostasis Cellular Response To Lithium Ion Postsynaptic Actin Cytoskeleton Organization Response To Lithium Ion Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Catabolic Process Regulation Of Organelle Organization NuA4 Histone Acetyltransferase Complex Apical Junction Complex Positive Regulation Of Macrophage Activation Maintenance Of Blood-brain Barrier Homeostatic Process Cellular Response To Metal Ion Anatomical Structure Homeostasis Tissue Homeostasis Kinesin Binding Platelet Aggregation Tau Protein Binding Regulation Of DNA Repair Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Vesicle-mediated Transport Basal Body Patch Negative Regulation Of MRNA 3'-end Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Integrated Proviral Latency Positive Regulation Of Organelle Organization Skeletal Muscle Hypertrophy Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Sulfite Oxidase Activity DNA Recombination Regulation Of Chromosome Organization	Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding
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