CAP1 and CAP2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		CAP1	CAP2
Description		cyclase associated actin cytoskeleton regulatory protein 1	cyclase associated actin cytoskeleton regulatory protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Focal Adhesion Membrane Cortical Actin Cytoskeleton Azurophil Granule Lumen Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Plasma Membrane Postsynaptic Density Membrane
	Molecular Function	Actin Binding Protein Binding Adenylate Cyclase Binding	Actin Binding Protein Binding Adenylate Cyclase Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Ameboidal-type Cell Migration Receptor-mediated Endocytosis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Actin Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton	Cell Morphogenesis Cytoskeleton Organization Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Presynaptic Actin Cytoskeleton Organization
Pathways		Platelet degranulation Role of ABL in ROBO-SLIT signaling Neutrophil degranulation	Role of ABL in ROBO-SLIT signaling
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Haemorrhoidal disease ( 33888516) Height ( 18391951) Mitochondrial DNA levels ( 25240745) QT interval ( 29213071) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834)
Interacting Genes		13 interacting genes: ACTB ACTG1 BARD1 CAP2 CEBPA CFTR FNDC3B LIG4 MYOC PLA2G4A SERPINB8 SNCA UCHL5	11 interacting genes: ACTG1 ADO ALAS1 CAP1 CFL2 DNM1L DSCAM GRXCR1 MT1P3 PRPF40A YWHAE
Entrez ID		10487	10486
HPRD ID		09869	10808
Ensembl ID		ENSG00000131236	ENSG00000112186
Uniprot IDs		D3DPU2 Q01518	B7Z385 E9PDI2 P40123
PDB IDs		1K8F
Enriched GO Terms of Interacting Partners?		Regulation Of Norepinephrine Uptake Transporter Regulator Activity Regulation Of Synaptic Vesicle Recycling Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Macrophage Activation Multicellular Organismal-level Homeostasis Cellular Response To Lithium Ion Postsynaptic Actin Cytoskeleton Organization Response To Lithium Ion Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Catabolic Process Regulation Of Organelle Organization NuA4 Histone Acetyltransferase Complex Apical Junction Complex Positive Regulation Of Macrophage Activation Maintenance Of Blood-brain Barrier Homeostatic Process Cellular Response To Metal Ion Anatomical Structure Homeostasis Tissue Homeostasis Kinesin Binding Platelet Aggregation Tau Protein Binding Regulation Of DNA Repair Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Vesicle-mediated Transport Basal Body Patch Negative Regulation Of MRNA 3'-end Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Integrated Proviral Latency Positive Regulation Of Organelle Organization Skeletal Muscle Hypertrophy Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Sulfite Oxidase Activity DNA Recombination Regulation Of Chromosome Organization
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