CAP1 and SERPINB8

Number of citations of the paper that reports this interaction (PMID 8761950)
6

Data Source:
HPRD (in vivo, two hybrid)

		CAP1	SERPINB8
Gene Name		CAP, adenylate cyclase-associated protein 1 (yeast)	serpin peptidase inhibitor, clade B (ovalbumin), member 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cortical Actin Cytoskeleton Extracellular Vesicular Exosome	Extracellular Space Cytosol Extracellular Vesicular Exosome
	Molecular Function	Actin Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Ameboidal-type Cell Migration Platelet Degranulation Receptor-mediated Endocytosis Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity Axon Guidance Blood Coagulation Actin Cytoskeleton Organization Platelet Activation	Negative Regulation Of Endopeptidase Activity
Pathways		Role of Abl in Robo-Slit signaling Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Signaling by Robo receptor	Dissolution of Fibrin Clot
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378)
Protein-Protein Interactions		9 interactors: ACTB ACTG1 BARD1 CAP2 LIG4 MYOC PLA2G4A SERPINB8 UCHL5	5 interactors: CAP1 F10 F2 FURIN PRSS1
Entrez ID		10487	5271
HPRD ID		09869	03412
Ensembl ID		ENSG00000131236	ENSG00000166401
Uniprot IDs		D3DPU2 Q01518	B4DTW2 P50452
PDB IDs		1K8F
Enriched GO Terms of Interacting Partners?		Tissue Homeostasis Platelet Activation Nervous System Development Cell Activation Multicellular Organismal Homeostasis Platelet Aggregation Generation Of Neurons Neuron Projection Development Neurogenesis Homotypic Cell-cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Retina Homeostasis Cellular Response To Stimulus Cell Development Neuron Development Axon Guidance ERBB2-ERBB3 Signaling Pathway DNA Ligation Involved In DNA Recombination Skeletal Muscle Hypertrophy Blood Coagulation Hemostasis Midbrain Development Adherens Junction Organization Neuron Differentiation Response To Stress Cell Projection Organization Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway ERBB2 Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Single Organismal Cell-cell Adhesion Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation DNA Repair Wound Healing Chemotaxis Response To Stimulus Neuron Projection Morphogenesis Platelet Activating Factor Biosynthetic Process System Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activating Factor Metabolic Process Response To Wounding Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process	Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Post-translational Protein Modification Blood Coagulation Hemostasis Proteolysis Regulation Of Body Fluid Levels Extracellular Matrix Disassembly Wound Healing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Proteolysis Response To Wounding Nerve Growth Factor Production Protein Activation Cascade Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Peptidyl-amino Acid Modification Platelet Activation Protein Metabolic Process Negative Regulation Of Cytokine Production Nerve Growth Factor Processing Blood Coagulation, Extrinsic Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cellular Protein Modification Process Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Viral Protein Processing Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Fibrinolysis Regulation Of Protein Processing Toll Signaling Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cobalamin Metabolic Process Signal Peptide Processing Secretion By Cell Cellular Protein Metabolic Process Virion Assembly Regulation Of Cytokine Production Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Activation Of Adenylate Cyclase Activity Regulation Of Astrocyte Differentiation
Tagcloud ?		alarco albicans balan brefeldin bzip caglr1 cai4 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants yap1	attracted botulinum c3 candidates decades dialysis disappointing displaying disturbance dominated epigenome finger h3k9me3 immunological mononuclear myh3 myosin nephrology nog noggin pcgf2 peptidase polycomb quantified rac3 seq throughput uremia
Tagcloud (Difference) ?		alarco albicans balan brefeldin bzip caglr1 cai4 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants yap1	attracted botulinum c3 candidates decades dialysis disappointing displaying disturbance dominated epigenome finger h3k9me3 immunological mononuclear myh3 myosin nephrology nog noggin pcgf2 peptidase polycomb quantified rac3 seq throughput uremia
Tagcloud (Intersection) ?