LUC7L and SRSF7

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LUC7L	SRSF7
Description		LUC7 like	serine and arginine rich splicing factor 7
Image		No pdb structure
GO Annotations	Cellular Component	U1 SnRNP U2-type Prespliceosome	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Extracellular Exosome
	Molecular Function	MRNA Binding Protein Binding Identical Protein Binding RS Domain Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	MRNA Splice Site Recognition Negative Regulation Of Striated Muscle Tissue Development	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 28453575 27863252 20139978 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		20 interacting genes: ANTKMT APPL1 CALM1 CHERP CLK2 CTNNBL1 DPYSL2 EIF4ENIF1 FBXO25 GADD45G PRDX1 PRMT5 SRPK2 SRRM4 SRSF1 SRSF6 SRSF7 SRSF8 TCERG1 TSC1	20 interacting genes: CCNL2 CDK19 CDK6 CEBPA CPSF6 DUSP11 FBXO7 LUC7L LUC7L2 NEDD4 NXF1 OGT PCBP2 PRPF38A RNPS1 SDCBP SREK1 SRPK1 SRPK2 UBC
Entrez ID		55692	6432
HPRD ID		08476	08991
Ensembl ID		ENSG00000007392	ENSG00000115875
Uniprot IDs		A8MYV2 Q1W6G4 Q9NQ29	C9JAB2 Q16629
PDB IDs			2HVZ
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Splicing Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Processing MRNA Metabolic Process MRNA Binding RNA Binding Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Nucleus Protein-RNA Complex Assembly Protein Kinase B Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Liver Regeneration Macromolecule Metabolic Process MRNA Splice Site Recognition Protein Methylation Regulation Of Cell Cycle Positive Regulation Of RNA Splicing Protein Localization To Nucleus Memory T Cell Differentiation Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Animal Organ Regeneration Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization To P-body Peptidyl-arginine N-methylation Positive Regulation Of Macropinocytosis Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Stabilization Identical Protein Binding	Nucleoplasm Nuclear Speck Nucleus RNA Binding MRNA Metabolic Process MRNA Binding MRNA Processing RNA Metabolic Process Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Splicing Protein-RNA Complex Assembly Regulation Of Cell Cycle U2-type Prespliceosome U1 SnRNP Macromolecule Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Protein Serine Kinase Activity Cyclin D2-CDK6 Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Formation Of Structure Involved In A Symbiotic Process Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Exon-exon Junction Complex Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Protein Targeting Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Response To Vitamin B2 C/EBP Complex Protein Localization To Lysosome Protein Modification Process Channel Inhibitor Activity
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