LUC7L and SRSF6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LUC7L	SRSF6
Description		LUC7 like	serine and arginine rich splicing factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	U1 SnRNP U2-type Prespliceosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	MRNA Binding Protein Binding Identical Protein Binding RS Domain Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding
	Biological Process	MRNA Splice Site Recognition Negative Regulation Of Striated Muscle Tissue Development	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Processing RNA Splicing Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Response To Insulin Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Wound Healing Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 28453575 27863252 20139978 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Adult body size ( 32376654) Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		20 interacting genes: ANTKMT APPL1 CALM1 CHERP CLK2 CTNNBL1 DPYSL2 EIF4ENIF1 FBXO25 GADD45G PRDX1 PRMT5 SRPK2 SRRM4 SRSF1 SRSF6 SRSF7 SRSF8 TCERG1 TSC1	16 interacting genes: APP CLK1 CRNDE LUC7L LUC7L2 OGT PPARGC1A RBM10 RNPS1 SF3B4 SREK1 SRPK1 SRSF4 TERF1 TERF2 TOE1
Entrez ID		55692	6431
HPRD ID		08476	09054
Ensembl ID		ENSG00000007392	ENSG00000124193
Uniprot IDs		A8MYV2 Q1W6G4 Q9NQ29	Q13247
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Splicing Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Processing MRNA Metabolic Process MRNA Binding RNA Binding Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Nucleus Protein-RNA Complex Assembly Protein Kinase B Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Liver Regeneration Macromolecule Metabolic Process MRNA Splice Site Recognition Protein Methylation Regulation Of Cell Cycle Positive Regulation Of RNA Splicing Protein Localization To Nucleus Memory T Cell Differentiation Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Animal Organ Regeneration Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization To P-body Peptidyl-arginine N-methylation Positive Regulation Of Macropinocytosis Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Stabilization Identical Protein Binding	RNA Splicing Nuclear Speck MRNA Processing Regulation Of RNA Splicing RNA Processing Nucleic Acid Binding MRNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Negative Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Shelterin Complex RNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Telomerase Activity RNA Binding Protein-RNA Complex Assembly Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding RNA Splicing, Via Transesterification Reactions G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Nucleus Telomere Capping Protein-containing Complex Assembly Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Macromolecule Metabolic Process U1 SnRNP Protein-containing Complex Organization Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Metabolic Process RNA-templated DNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process MRNA Splice Site Recognition Negative Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway
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