ADARB1 and TARBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADARB1	TARBP2
Description		adenosine deaminase RNA specific B1	TARBP2 subunit of RISC loading complex
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding Protein Sequestering Activity
	Biological Process	Immune System Process Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Translation Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization Post-transcriptional Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Multicellular Organism Growth Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Regulation Of Protein Metabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination Regulation Of Regulatory NcRNA Processing Regulation Of SiRNA Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage Regulation Of MiRNA Processing
Pathways		C6 deamination of adenosine Formation of editosomes by ADAR proteins	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Body mass index ( 25673413 28892062) Gastroesophageal reflux disease ( 34187846) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mild obesity-related type 2 diabetes ( 34737425) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		63 interacting genes: APP DCN EDIL3 EHHADH EIF2AK2 LARP6 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF NVL PIN1 PNPT1 PRKRA RBFOX2 RSL1D1 SNRNP70 STAU1 STOX1 STRBP SURF6 TARBP2 TCEANC UBE2I USP7 ZMAT4 ZNF346	32 interacting genes: ADARB1 AGO2 APP CDK9 DICER1 EIF2AK2 FOXP1 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NKRF NUDT18 OGT PNKP PRKRA RBM14 RNF10 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346
Entrez ID		104	6895
HPRD ID		06777	05446
Ensembl ID		ENSG00000197381	ENSG00000139546
Uniprot IDs		A0A994J4V7 A0A994J7T5 P78563	Q15633
PDB IDs		1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF 7KFN 8E0F 8E4X 9D5J 9D5K	2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM 6ZBK
Enriched GO Terms of Interacting Partners?		RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Vesicle Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration	Double-stranded RNA Binding Nucleus Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Regulation Of Primary Metabolic Process Pre-miRNA Processing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nucleic Acid Binding Regulation Of Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm MiRNA Processing Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Defense Response To Symbiont Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Defense Response To Other Organism RNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Pre-miRNA Binding Response To External Biotic Stimulus Regulation Of Macromolecule Biosynthetic Process Defense Response Innate Immune Response Response To Other Organism Apoptotic Process Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Nucleolus Regulation Of Programmed Cell Death Endonuclease Activity Regulation Of Developmental Process Response To Stress Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration
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