ADARB1 and STOX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADARB1	STOX1
Description		adenosine deaminase RNA specific B1	storkhead box 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Cell Cortex
	Molecular Function	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Immune System Process Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Inner Ear Development Cell Division Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Nitrosative Stress Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitochondrial DNA Metabolic Process Regulation Of Response To Oxidative Stress Positive Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Otic Vesicle Morphogenesis
Pathways		C6 deamination of adenosine Formation of editosomes by ADAR proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Body mass index ( 25673413 28892062) Gastroesophageal reflux disease ( 34187846) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mild obesity-related type 2 diabetes ( 34737425) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		63 interacting genes: APP DCN EDIL3 EHHADH EIF2AK2 LARP6 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF NVL PIN1 PNPT1 PRKRA RBFOX2 RSL1D1 SNRNP70 STAU1 STOX1 STRBP SURF6 TARBP2 TCEANC UBE2I USP7 ZMAT4 ZNF346	8 interacting genes: ADARB1 AKT1 BANP GCLM GORASP2 NFYC POU2F1 ROR2
Entrez ID		104	219736
HPRD ID		06777	18579
Ensembl ID		ENSG00000197381	ENSG00000165730
Uniprot IDs		A0A994J4V7 A0A994J7T5 P78563	Q6ZVD7
PDB IDs		1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF 7KFN 8E0F 8E4X 9D5J 9D5K
Enriched GO Terms of Interacting Partners?		RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Vesicle Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration	Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Hypoglossal Nerve Morphogenesis Deaminase Activity TRNA-specific Adenosine Deaminase Activity Adenosine To Inosine Editing RNA Modification Adenosine Deaminase Activity Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric-oxide Synthase Regulator Activity Glucose Homeostasis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Negative Regulation Of Neuron Apoptotic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Apoptotic Mitochondrial Changes Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
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