ADARB1 and SURF6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ADARB1	SURF6
Description		adenosine deaminase RNA specific B1	surfeit 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	Granular Component Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	DNA Binding RNA Binding Protein Binding Molecular Condensate Scaffold Activity
	Biological Process	Immune System Process Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process	Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		C6 deamination of adenosine Formation of editosomes by ADAR proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Body mass index ( 25673413 28892062) Gastroesophageal reflux disease ( 34187846) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mild obesity-related type 2 diabetes ( 34737425) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels in cardiovascular risk ( 28369058) Coagulation factor levels ( 23267103) Epithelial ovarian cancer ( 25134534) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Malaria ( 31844061) Serum alkaline phosphatase levels ( 24094242) Tonsillectomy ( 28928442 27182965) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		63 interacting genes: APP DCN EDIL3 EHHADH EIF2AK2 LARP6 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF NVL PIN1 PNPT1 PRKRA RBFOX2 RSL1D1 SNRNP70 STAU1 STOX1 STRBP SURF6 TARBP2 TCEANC UBE2I USP7 ZMAT4 ZNF346	6 interacting genes: ADARB1 CSNK2A1 FAM9B RBFOX2 RBM4 RPL22
Entrez ID		104	6838
HPRD ID		06777	01714
Ensembl ID		ENSG00000197381	ENSG00000148296
Uniprot IDs		A0A994J4V7 A0A994J7T5 P78563	O75683
PDB IDs		1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF 7KFN 8E0F 8E4X 9D5J 9D5K	8FKP 8FKQ 8FKR 8FKS
Enriched GO Terms of Interacting Partners?		RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Vesicle Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration	MRNA Metabolic Process MRNA Binding Hypoglossal Nerve Morphogenesis MRNA Processing Negative Regulation Of Translational Initiation Cap-independent Translational Initiation Regulation Of Alternative MRNA Splicing, Via Spliceosome IRES-dependent Translational Initiation Of Linear MRNA Translation At Presynapse RNA Metabolic Process Regulation Of Translational Initiation Pre-mRNA Intronic Pyrimidine-rich Binding Circadian Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Negative Regulation Of Protein Metabolic Process Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of MRNA Processing Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Adenosine To Inosine Editing Negative Regulation Of Translation Positive Regulation Of Aggrephagy Regulation Of RNA Splicing TRNA-specific Adenosine Deaminase Activity RNA Processing Adenosine Deaminase Activity Nucleic Acid Metabolic Process Nucleus Deaminase Activity Nucleoplasm Rhythmic Process Negative Regulation Of Translation In Response To Stress Double-strand Break Repair Via Classical Nonhomologous End Joining Insulin Secretion Involved In Cellular Response To Glucose Stimulus Pre-mRNA Intronic Binding Neuromuscular Process Controlling Posture Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cranial Nerve Morphogenesis Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Motor Neuron Apoptotic Process Regulation Of MRNA Metabolic Process Enteroendocrine Cell Differentiation Nucleobase-containing Compound Metabolic Process Base Conversion Or Substitution Editing Negative Regulation Of Macromolecule Metabolic Process
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